Minimal change disease in a patient receiving checkpoint inhibition: Another possible manifestation of kidney autoimmunity?
Cancer Rep (Hoboken)
; 3(5): e1250, 2020 10.
Article
en En
| MEDLINE
| ID: mdl-33085845
ABSTRACT
BACKGROUND:
Nivolumab has been associated with immune-related adverse events, including nephritis, with acute interstitial nephritis being the most commonly reported renal manifestation. CASE We describe the first case to our knowledge of minimal change disease with nephrotic syndrome associated with the PD-1 checkpoint inhibitor, Nivolumab. Minimal change disease has been reported with other immune checkpoint inhibitors; however, this is the first reported case with Nivolumab. We report development of nephrotic syndrome with acute kidney injury in a 57-year-old man, 1 month after commencement of Nivolumab for metastatic squamous cell carcinoma of the tongue. Minimal change disease was confirmed by renal biopsy. Management with corticosteroids and cessation of Nivolumab failed to improve kidney function or nephrosis.CONCLUSION:
This case adds to current literature identifying minimal change as an additional complication of immune checkpoint inhibitor-associated acute kidney injury. Given the increasing use of immune checkpoint inhibitors for a range of malignancies, nephrologists, oncologist and generalists should be aware of the spectrum of kidney pathologies associated with their use.Palabras clave
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Neoplasias de la Lengua
/
Autoinmunidad
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Carcinoma de Células Escamosas de Cabeza y Cuello
/
Nivolumab
/
Nefrosis Lipoidea
Tipo de estudio:
Prognostic_studies
Límite:
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Cancer Rep (Hoboken)
Año:
2020
Tipo del documento:
Article
País de afiliación:
Australia