Multiple System Atrophy (MSA) and smoking: a meta-analysis and mechanistic insights.
Aging (Albany NY)
; 12(21): 21959-21970, 2020 11 07.
Article
en En
| MEDLINE
| ID: mdl-33161394
ABSTRACT
BACKGROUND:
The association between cigarette smoking and multiple system atrophy (MSA) has been debated. We conducted a systematic review and a meta-analysis to investigate this link.RESULTS:
We identified 161 articles from database searching and bibliographic review. Five case-control studies satisfied the inclusion and exclusion criteria, and 435 and 352 healthy controls and MSA patients were examined. The prevalence of MSA amongst ever smokers was lower compared to never smokers (aOR=0.57; 95% CI, 0.29-1.14), although this result did not reach statistical significance. This was also observed for current and former smokers, with a stronger association for current smokers (aOR=0.63 vs aOR=0.96).CONCLUSIONS:
There is a suggestion that smoking protects against MSA. Prospective studies in larger patient cohorts are required to further evaluate the cause-effect relationship and functional studies in cellular and animal models will provide mechanistic insights on their potential etiologic links.METHODS:
PubMed and Cochrane Library were searched from inception to July 7, 2019 to identify case-control studies that analyzed smoking as an environmental risk or protective factor for MSA. Two authors independently extracted data and performed risk-of-bias and quality assessment. The random-effects model was assumed to account for between-study variance when pooling the crude and adjusted odds ratios.Palabras clave
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Fumar
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Atrofia de Múltiples Sistemas
Tipo de estudio:
Observational_studies
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Prevalence_studies
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Prognostic_studies
/
Risk_factors_studies
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Systematic_reviews
Límite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Aging (Albany NY)
Asunto de la revista:
GERIATRIA
Año:
2020
Tipo del documento:
Article
País de afiliación:
Singapur