MicroRNA-23a-3p Down-Regulation in Active Pulmonary Tuberculosis Patients with High Bacterial Burden Inhibits Mononuclear Cell Function and Phagocytosis through TLR4/TNF-&#945;/TGF-ß1/IL-10 Signaling via Targeting IRF1/SP1.

Chen, Yung-Che; Lee, Chiu Ping; Hsiao, Chang-Chun; Hsu, Po-Yuan; Wang, Ting-Ya; Wu, Chao-Chien; Chao, Tung-Ying; Leung, Sum-Yee; Chang, Yu-Ping; Lin, Meng-Chih

MicroRNA-23a-3p Down-Regulation in Active Pulmonary Tuberculosis Patients with High Bacterial Burden Inhibits Mononuclear Cell Function and Phagocytosis through TLR4/TNF-α/TGF-ß1/IL-10 Signaling via Targeting IRF1/SP1.

Chen, Yung-Che; Lee, Chiu Ping; Hsiao, Chang-Chun; Hsu, Po-Yuan; Wang, Ting-Ya; Wu, Chao-Chien; Chao, Tung-Ying; Leung, Sum-Yee; Chang, Yu-Ping; Lin, Meng-Chih.

Afiliación

Chen YC; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan.
Lee CP; Department of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.
Hsiao CC; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan.
Hsu PY; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan.
Wang TY; Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.
Wu CC; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan.
Chao TY; Department of Medical Research, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan.
Leung SY; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan.
Chang YP; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan.
Lin MC; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan.

Int J Mol Sci ; 21(22)2020 Nov 14.

Article en En | MEDLINE | ID: mdl-33202583

Asunto(s)

Regulación hacia Abajo; Factor 1 Regulador del Interferón/metabolismo; Interleucina-10/metabolismo; MicroARNs/biosíntesis; Mycobacterium tuberculosis/metabolismo; Fagocitosis; Transducción de Señal; Factor de Transcripción Sp1/metabolismo; Receptor Toll-Like 4/metabolismo; Factor de Crecimiento Transformador beta1/metabolismo; Tuberculosis Pulmonar/metabolismo; Factor de Necrosis Tumoral alfa/metabolismo; Femenino; Humanos; Factor 1 Regulador del Interferón/genética; Interleucina-10/genética; Masculino; MicroARNs/genética; Factor de Transcripción Sp1/genética; Células THP-1; Receptor Toll-Like 4/genética; Factor de Crecimiento Transformador beta1/genética; Tuberculosis Pulmonar/genética; Factor de Necrosis Tumoral alfa/genética

Palabras clave

IL10; TLR4; active pulmonary TB disease; latent TB infection; miR-23a-3p

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Texto completo: 1 Colección: 01-internacional Asunto principal: Fagocitosis / Tuberculosis Pulmonar / Transducción de Señal / Regulación hacia Abajo / Factor de Transcripción Sp1 / Factor de Necrosis Tumoral alfa / Interleucina-10 / MicroARNs / Factor 1 Regulador del Interferón / Receptor Toll-Like 4 Tipo de estudio: Prognostic_studies Límite: Female / Humans / Male Idioma: En Revista: Int J Mol Sci Año: 2020 Tipo del documento: Article País de afiliación: Taiwán

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