Vagal-&#945;7nAChR signaling is required for lung anti-inflammatory responses and arginase 1 expression during an influenza infection.

Gao, Zhao-Wei; Li, Ling; Huang, Yuan-Yuan; Zhao, Cai-Qi; Xue, Shuang-Jia; Chen, Jie; Yang, Zhong-Zhou; Xu, Jin-Fu; Su, Xiao

Vagal-α7nAChR signaling is required for lung anti-inflammatory responses and arginase 1 expression during an influenza infection.

Gao, Zhao-Wei; Li, Ling; Huang, Yuan-Yuan; Zhao, Cai-Qi; Xue, Shuang-Jia; Chen, Jie; Yang, Zhong-Zhou; Xu, Jin-Fu; Su, Xiao.

Afiliación

Gao ZW; Unit of Respiratory Infection and Immunity, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, 200031, China.
Li L; Unit of Respiratory Infection and Immunity, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, 200031, China.
Huang YY; Unit of Respiratory Infection and Immunity, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, 200031, China.
Zhao CQ; Unit of Respiratory Infection and Immunity, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, 200031, China.
Xue SJ; Unit of Respiratory Infection and Immunity, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, 200031, China.
Chen J; Unit of Respiratory Infection and Immunity, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, 200031, China.
Yang ZZ; MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing Biomedical Research Institute, Nanjing University, Nanjing, 210061, China.
Xu JF; Department of Pulmonary and Critical Care Medicine, Shanghai Pulmonary Hospital, Tongji University, Shanghai, 200433, China. jfxucn@gmail.com.
Su X; Unit of Respiratory Infection and Immunity, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, 200031, China. xsu@ips.ac.cn.

Acta Pharmacol Sin ; 42(10): 1642-1652, 2021 Oct.

Article en En | MEDLINE | ID: mdl-33414508

Asunto(s)

Arginasa/metabolismo; Inflamación/metabolismo; Gripe Humana/metabolismo; Pulmón/metabolismo; Transducción de Señal/fisiología; Receptor Nicotínico de Acetilcolina alfa 7/metabolismo; Animales; Proteína Forkhead Box O1/metabolismo; Técnicas de Inactivación de Genes; Humanos; Interleucina-4/metabolismo; Histona Demetilasas con Dominio de Jumonji/metabolismo; Macrófagos/enzimología; Macrófagos/metabolismo; Masculino; Ratones Endogámicos C57BL; Ratones Noqueados; Proteínas Proto-Oncogénicas c-akt/metabolismo; Factor de Transcripción STAT6/metabolismo; Bazo/metabolismo; Vagotomía; Nervio Vago/metabolismo; Nervio Vago/cirugía; Receptor Nicotínico de Acetilcolina alfa 7/genética

Palabras clave

arginase 1; influenza A virus; lung inflammation; vagus circuits; α7nAChR

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Texto completo: 1 Colección: 01-internacional Asunto principal: Arginasa / Transducción de Señal / Gripe Humana / Receptor Nicotínico de Acetilcolina alfa 7 / Inflamación / Pulmón Límite: Animals / Humans / Male Idioma: En Revista: Acta Pharmacol Sin Asunto de la revista: FARMACOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: China

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