TAK1-TABs Complex: A Central Signalosome in Inflammatory Responses.
Front Immunol
; 11: 608976, 2020.
Article
en En
| MEDLINE
| ID: mdl-33469458
ABSTRACT
Transforming growth factor-ß (TGF-ß)-activated kinase 1 (TAK1) is a member of the MAPK kinase kinase (MAPKKK) family and has been implicated in the regulation of a wide range of physiological and pathological processes. TAK1 functions through assembling with its binding partners TAK1-binding proteins (TAB1, TAB2, and TAB3) and can be activated by a variety of stimuli such as tumor necrosis factor α (TNFα), interleukin-1ß (IL-1ß), and toll-like receptor ligands, and they play essential roles in the activation of NF-κB and MAPKs. Numerous studies have demonstrated that post-translational modifications play important roles in properly controlling the activity, stability, and assembly of TAK1-TABs complex according to the indicated cellular environment. This review focuses on the recent advances in TAK1-TABs-mediated signaling and the regulations of TAK1-TABs complex by post-translational modifications.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Factor de Necrosis Tumoral alfa
/
Quinasas Quinasa Quinasa PAM
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Proteínas Adaptadoras Transductoras de Señales
/
Inflamación
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Front Immunol
Año:
2020
Tipo del documento:
Article
País de afiliación:
China