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Implementing Zn2+ ion and pH-value control into artificial mussel glue proteins by abstracting a His-rich domain from preCollagen.
Arias, Sandra; Amini, Shahrouz; Krüger, Jana M; Bangert, Lukas D; Börner, Hans G.
Afiliación
  • Arias S; Humboldt-Universität zu Berlin, Department of Chemistry, Laboratory for Organic Synthesis of Functional Systems, Brook-Taylor-Str. 2, Berlin D-12489, Germany. h.boerner@HU-Berlin.de.
  • Amini S; Max Planck Institute of Colloids and Interfaces, Department of Biomaterials, Potsdam 14424, Germany.
  • Krüger JM; Humboldt-Universität zu Berlin, Department of Chemistry, Laboratory for Organic Synthesis of Functional Systems, Brook-Taylor-Str. 2, Berlin D-12489, Germany. h.boerner@HU-Berlin.de.
  • Bangert LD; Humboldt-Universität zu Berlin, Department of Chemistry, Laboratory for Organic Synthesis of Functional Systems, Brook-Taylor-Str. 2, Berlin D-12489, Germany. h.boerner@HU-Berlin.de.
  • Börner HG; Humboldt-Universität zu Berlin, Department of Chemistry, Laboratory for Organic Synthesis of Functional Systems, Brook-Taylor-Str. 2, Berlin D-12489, Germany. h.boerner@HU-Berlin.de.
Soft Matter ; 17(8): 2028-2033, 2021 Mar 04.
Article en En | MEDLINE | ID: mdl-33596288
ABSTRACT
A His-rich domain of preCollagen-D found in byssal threads is derivatized with Cys and Dopa flanks to allow for mussel-inspired polymerization. Artificial mussel glue proteins are accessed that combine cysteinyldopa for adhesion with sequences for pH or Zn2+ induced ß-sheet formation. The artificial constructs show strong adsorption to Al2O3, the resulting coatings tolerate hypersaline conditions and cohesion is improved by activating the ß-sheet formation, that enhances E-modulus up to 60%.
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Texto completo: 1 Colección: 01-internacional Asunto principal: Dihidroxifenilalanina / Conformación Proteica en Lámina beta Límite: Animals Idioma: En Revista: Soft Matter Año: 2021 Tipo del documento: Article País de afiliación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Asunto principal: Dihidroxifenilalanina / Conformación Proteica en Lámina beta Límite: Animals Idioma: En Revista: Soft Matter Año: 2021 Tipo del documento: Article País de afiliación: Alemania