Entropy-Driven Quick Loading of Functional Proteins in Nanohydrogels for Highly Efficient Tumor Targeting Therapy.

Sun, Jiaxin; Li, Yongjing; Wang, Xiuli; Fei, Weiwei; Guo, Jia; Wang, Changchun

Sun, Jiaxin; Li, Yongjing; Wang, Xiuli; Fei, Weiwei; Guo, Jia; Wang, Changchun.

Afiliación

Sun J; State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, and Laboratory of Advanced Materials, Fudan University, Shanghai 200438, P. R. China.
Li Y; State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, and Laboratory of Advanced Materials, Fudan University, Shanghai 200438, P. R. China.
Wang X; State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, and Laboratory of Advanced Materials, Fudan University, Shanghai 200438, P. R. China.
Fei W; State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, and Laboratory of Advanced Materials, Fudan University, Shanghai 200438, P. R. China.
Guo J; State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, and Laboratory of Advanced Materials, Fudan University, Shanghai 200438, P. R. China.
Wang C; State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, and Laboratory of Advanced Materials, Fudan University, Shanghai 200438, P. R. China.

ACS Appl Mater Interfaces ; 13(11): 12888-12898, 2021 Mar 24.

Article en En | MEDLINE | ID: mdl-33715358

Asunto(s)

Resinas Acrílicas/química; Portadores de Fármacos/química; Hidrogeles/química; Neoplasias/tratamiento farmacológico; Proteínas/administración & dosificación; Animales; Sistemas de Liberación de Medicamentos; Entropía; Células Hep G2; Humanos; Ratones Endogámicos ICR; Ratones Desnudos; Nanoestructuras/química; Neoplasias/patología; Proteínas/farmacocinética; Proteínas/uso terapéutico; Ricina/administración & dosificación; Ricina/farmacocinética; Albúmina Sérica Humana/administración & dosificación; Albúmina Sérica Humana/farmacocinética; Albúmina Sérica Humana/uso terapéutico; Transferrina/administración & dosificación; Transferrina/farmacocinética; Transferrina/uso terapéutico

Palabras clave

drug delivery; entropy driven; nanohydrogels; proteins; tumor targeting therapy

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Texto completo: 1 Colección: 01-internacional Asunto principal: Resinas Acrílicas / Portadores de Fármacos / Proteínas / Hidrogeles / Neoplasias Límite: Animals / Humans Idioma: En Revista: ACS Appl Mater Interfaces Asunto de la revista: BIOTECNOLOGIA / ENGENHARIA BIOMEDICA Año: 2021 Tipo del documento: Article

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