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Liquid Biopsies in the Clinical Management of Germ Cell Tumor Patients: State-of-the-Art and Future Directions.
Lobo, João; Leão, Ricardo; Jerónimo, Carmen; Henrique, Rui.
Afiliación
  • Lobo J; Cancer Biology and Epigenetics Group, IPO Porto Research Center (GEBC CI-IPOP), Portuguese Oncology Institute of Porto (IPO Porto) & Porto Comprehensive Cancer Center (P.CCC), R. Dr. António Bernardino de Almeida, 4200-072 Porto, Portugal.
  • Leão R; Department of Pathology, Portuguese Oncology Institute of Porto (IPOP), R. Dr. António Bernardino de Almeida, 4200-072 Porto, Portugal.
  • Jerónimo C; Department of Pathology and Molecular Immunology, Institute of Biomedical Sciences Abel Salazar, University of Porto (ICBAS-UP), Rua Jorge Viterbo Ferreira 228, 4050-513 Porto, Portugal.
  • Henrique R; Faculty of Medicine, University of Coimbra, Rua Larga, 3000-370 Coimbra, Portugal.
Int J Mol Sci ; 22(5)2021 Mar 06.
Article en En | MEDLINE | ID: mdl-33800799
ABSTRACT
Liquid biopsies constitute a minimally invasive means of managing cancer patients, entailing early diagnosis, follow-up and prediction of response to therapy. Their use in the germ cell tumor field is invaluable since diagnostic tissue biopsies (which are invasive) are often not performed, and therefore only a presumptive diagnosis can be made, confirmed upon examination of the surgical specimen. Herein, we provide an overall review of the current liquid biopsy-based biomarkers of this disease, including the classical, routinely used serum tumor markers-the promising microRNAs rapidly approaching the introduction into clinical practice-but also cell-free DNA markers (including DNA methylation) and circulating tumor cells. Finally, and importantly, we also explore novel strategies and challenges for liquid biopsy markers and methodologies, providing a critical view of the future directions for liquid biopsy tests in this field, highlighting gaps and unanswered questions.
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Texto completo: 1 Colección: 01-internacional Asunto principal: Neoplasias de Células Germinales y Embrionarias / Biopsia Líquida Tipo de estudio: Diagnostic_studies / Guideline / Prognostic_studies / Screening_studies Límite: Female / Humans / Male Idioma: En Revista: Int J Mol Sci Año: 2021 Tipo del documento: Article País de afiliación: Portugal

Texto completo: 1 Colección: 01-internacional Asunto principal: Neoplasias de Células Germinales y Embrionarias / Biopsia Líquida Tipo de estudio: Diagnostic_studies / Guideline / Prognostic_studies / Screening_studies Límite: Female / Humans / Male Idioma: En Revista: Int J Mol Sci Año: 2021 Tipo del documento: Article País de afiliación: Portugal