Complement activation by an angiogenic imbalance leads to systemic vascular endothelial dysfunction: A new proposal for the pathophysiology of preeclampsia.

Matsuyama, Tatsuya; Tomimatsu, Takuji; Mimura, Kazuya; Yagi, Kazunobu; Kawanishi, Yoko; Kakigano, Aiko; Nakamura, Hitomi; Endo, Masayuki; Kimura, Tadashi

Matsuyama, Tatsuya; Tomimatsu, Takuji; Mimura, Kazuya; Yagi, Kazunobu; Kawanishi, Yoko; Kakigano, Aiko; Nakamura, Hitomi; Endo, Masayuki; Kimura, Tadashi.

Afiliación

Matsuyama T; Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
Tomimatsu T; Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan. Electronic address: tomimatsu@gyne.med.osaka-u.ac.jp.
Mimura K; Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
Yagi K; Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
Kawanishi Y; Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
Kakigano A; Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
Nakamura H; Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
Endo M; Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
Kimura T; Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.

J Reprod Immunol ; 145: 103322, 2021 06.

Article en En | MEDLINE | ID: mdl-33887508

Asunto(s)

Activación de Complemento; Preeclampsia/inmunología; Estudios de Casos y Controles; Supervivencia Celular/inmunología; Células Cultivadas; Factor H de Complemento/metabolismo; Complejo de Ataque a Membrana del Sistema Complemento/metabolismo; Endotelio Vascular/patología; Femenino; Células Endoteliales de la Vena Umbilical Humana; Humanos; Neovascularización Fisiológica/inmunología; Placenta/irrigación sanguínea; Placenta/inmunología; Placenta/patología; Factor de Crecimiento Placentario/metabolismo; Preeclampsia/patología; Embarazo; Cultivo Primario de Células; Receptor 1 de Factores de Crecimiento Endotelial Vascular/metabolismo

Palabras clave

Angiogenic imbalance; Complement activation; Complement factor H; Placental growth factor; Preeclampsia; Vascular endothelial dysfunction

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Texto completo: 1 Colección: 01-internacional Asunto principal: Preeclampsia / Activación de Complemento Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Female / Humans / Pregnancy Idioma: En Revista: J Reprod Immunol Año: 2021 Tipo del documento: Article País de afiliación: Japón

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