Phosphorylation of the androgen receptor at Ser81 is co-sustained by CDK1 and CDK9 and leads to AR-mediated transactivation in prostate cancer.

Gao, XinTao; Liang, Jiaqian; Wang, LiYang; Zhang, Zhaoyang; Yuan, Penghui; Wang, Jiaxin; Gao, Yanfei; Ma, Fen; Calagua, Carla; Ye, Huihui; Voznesensky, Olga; Wang, Shaogang; Wang, Tao; Liu, Jihong; Chen, Shaoyong; Liu, Xiaming

Gao, XinTao; Liang, Jiaqian; Wang, LiYang; Zhang, Zhaoyang; Yuan, Penghui; Wang, Jiaxin; Gao, Yanfei; Ma, Fen; Calagua, Carla; Ye, Huihui; Voznesensky, Olga; Wang, Shaogang; Wang, Tao; Liu, Jihong; Chen, Shaoyong; Liu, Xiaming.

Afiliación

Gao X; Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Liang J; Hematology-Oncology Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Wang L; Wuhan No. 1 Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Zhang Z; Hematology-Oncology Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Yuan P; Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, College of Basic Medicine, Hubei University of Medicine, Shiyan, China.
Wang J; Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Gao Y; Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Ma F; Department of Orthopaedic Surgery, The Second Affiliated Hospital, Chongqing Medical University, China.
Calagua C; Hematology-Oncology Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Ye H; Hematology-Oncology Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Voznesensky O; Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Wang S; Department of Pathology, University of California Los Angeles, CA, USA.
Wang T; Hematology-Oncology Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Liu J; Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Chen S; Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Liu X; Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Mol Oncol ; 15(7): 1901-1920, 2021 07.

Article en En | MEDLINE | ID: mdl-33932081

Asunto(s)

Neoplasias de la Próstata Resistentes a la Castración; Neoplasias de la Próstata; Proteína Quinasa CDC2/genética; Proteína Quinasa CDC2/metabolismo; Línea Celular Tumoral; Quinasa 9 Dependiente de la Ciclina/genética; Quinasa 9 Dependiente de la Ciclina/metabolismo; Humanos; Masculino; Fosforilación; Neoplasias de la Próstata/patología; Neoplasias de la Próstata Resistentes a la Castración/genética; Neoplasias de la Próstata Resistentes a la Castración/metabolismo; Receptores Androgénicos/genética; Receptores Androgénicos/metabolismo; Activación Transcripcional/genética

Palabras clave

CDK1; CDK9; ChIP-Seq; androgen receptor; enhancer-promoter loop; serine 81 phosphorylation

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Texto completo: 1 Colección: 01-internacional Asunto principal: Neoplasias de la Próstata / Neoplasias de la Próstata Resistentes a la Castración Límite: Humans / Male Idioma: En Revista: Mol Oncol Asunto de la revista: BIOLOGIA MOLECULAR / NEOPLASIAS Año: 2021 Tipo del documento: Article País de afiliación: China

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