Targeting hyperactive TGFBR2 for treating MYOCD deficient lung cancer.
Theranostics
; 11(13): 6592-6606, 2021.
Article
en En
| MEDLINE
| ID: mdl-33995678
ABSTRACT
Purpose:
Clinical success of cancer therapy is severely limited by drug resistance, attributed in large part to the loss of function of tumor suppressor genes (TSGs). Developing effective strategies to treat those tumors is challenging, but urgently needed in clinic. ExperimentalDesign:
MYOCD is a clinically relevant TSG in lung cancer patients. Our in vitro and in vivo data confirm its tumor suppressive function. Further analysis reveals that MYOCD potently inhibits stemness of lung cancer stem cells. Mechanistically, MYOCD localizes to TGFBR2 promoter region and thereby recruits PRMT5/MEP50 complex to epigenetically silence its transcription.Conclusions:
NSCLC cells deficient of MYOCD are particularly sensitive to TGFBR kinase inhibitor (TGFBRi). TGFBRi and stemness inhibitor synergize with existing drugs to treat MYOCD deficient lung cancers. Our current work shows that loss of function of MYOCD creates Achilles' heels in lung cancer cells, which might be exploited in clinic.Palabras clave
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Proteínas Nucleares
/
Transactivadores
/
Carcinoma de Pulmón de Células no Pequeñas
/
Receptor Tipo II de Factor de Crecimiento Transformador beta
/
Neoplasias Pulmonares
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Proteínas de Neoplasias
Idioma:
En
Revista:
Theranostics
Año:
2021
Tipo del documento:
Article
País de afiliación:
China