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Tumor-on-chip modeling of organ-specific cancer and metastasis.
Del Piccolo, Nuala; Shirure, Venktesh S; Bi, Ye; Goedegebuure, S Peter; Gholami, Sepideh; Hughes, Christopher C W; Fields, Ryan C; George, Steven C.
Afiliación
  • Del Piccolo N; Department of Biomedical Engineering, University of California, Davis, One Shields Ave, Davis, CA 95616, United States.
  • Shirure VS; Department of Biomedical Engineering, University of California, Davis, One Shields Ave, Davis, CA 95616, United States.
  • Bi Y; Department of Surgery, The Alvin J. Siteman Cancer Center, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, MO 63110-1010, United States.
  • Goedegebuure SP; Department of Surgery, The Alvin J. Siteman Cancer Center, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, MO 63110-1010, United States.
  • Gholami S; Department of Surgery, University of California, Davis, 2335 Stockton Boulevard, Sacramento, CA 95817, United States.
  • Hughes CCW; Department of Molecular Biology & Biochemistry and Department of Biomedical Engineering, University of California, Irvine, CA 92697-3900, United States.
  • Fields RC; Department of Surgery, The Alvin J. Siteman Cancer Center, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, MO 63110-1010, United States.
  • George SC; Department of Biomedical Engineering, University of California, Davis, One Shields Ave, Davis, CA 95616, United States. Electronic address: scgeorge@ucdavis.edu.
Adv Drug Deliv Rev ; 175: 113798, 2021 08.
Article en En | MEDLINE | ID: mdl-34015419
ABSTRACT
Every year, cancer claims millions of lives around the globe. Unfortunately, model systems that accurately mimic human oncology - a requirement for the development of more effective therapies for these patients - remain elusive. Tumor development is an organ-specific process that involves modification of existing tissue features, recruitment of other cell types, and eventual metastasis to distant organs. Recently, tissue engineered microfluidic devices have emerged as a powerful in vitro tool to model human physiology and pathology with organ-specificity. These organ-on-chip platforms consist of cells cultured in 3D hydrogels and offer precise control over geometry, biological components, and physiochemical properties. Here, we review progress towards organ-specific microfluidic models of the primary and metastatic tumor microenvironments. Despite the field's infancy, these tumor-on-chip models have enabled discoveries about cancer immunobiology and response to therapy. Future work should focus on the development of autologous or multi-organ systems and inclusion of the immune system.
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Texto completo: 1 Colección: 01-internacional Asunto principal: Dispositivos Laboratorio en un Chip / Metástasis de la Neoplasia / Neoplasias Límite: Animals / Humans Idioma: En Revista: Adv Drug Deliv Rev Asunto de la revista: FARMACOLOGIA / TERAPIA POR MEDICAMENTOS Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Asunto principal: Dispositivos Laboratorio en un Chip / Metástasis de la Neoplasia / Neoplasias Límite: Animals / Humans Idioma: En Revista: Adv Drug Deliv Rev Asunto de la revista: FARMACOLOGIA / TERAPIA POR MEDICAMENTOS Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos