Prognostic significance of T cells, PD-L1 immune checkpoint and tumour associated macrophages in clear cell carcinoma of the ovary.
Gynecol Oncol
; 162(2): 421-430, 2021 08.
Article
en En
| MEDLINE
| ID: mdl-34088514
ABSTRACT
OBJECTIVE:
To define the pre-treatment tumour immune landscape of clear cell carcinoma of the ovary (CCOC).METHODS:
We investigated the infiltration profiles of selected immune cell populations and immune checkpoint proteins that have been previously shown to have prognostic relevance in high grade serous carcinoma of the ovary to determine their association with clinical outcomes in CCOC patients. Using multiplex immunohistochemistry, we evaluated the density of CD3+, FoxP3+, CD8+ T cells, CD20+ B cells and expression of PD-1, PD-L1 and IDO1 immune checkpoints in a cohort of 162 CCOC tumour specimens on a tissue microarray.RESULTS:
Increased infiltration of CD3+ CD8- (helper T) cells, CD8+ (cytotoxic T) cells, and CD68+ macrophages significantly associated with shorter disease-free survival, recurrence-free survival and overall survival. Importantly, higher expression of PD-L1 and IDO-1 immune checkpoints was associated with better clinical outcomes.CONCLUSION:
Findings from our study are foundational towards the development of immune classifiers and biomarkers of response to immune checkpoint blockade therapy in CCOC.
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Neoplasias Ováricas
/
Ovario
/
Carcinoma
/
Microambiente Tumoral
/
Recurrencia Local de Neoplasia
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
Idioma:
En
Revista:
Gynecol Oncol
Año:
2021
Tipo del documento:
Article
País de afiliación:
Canadá