Urinary Free Metanephrines for Diagnosis of Pheochromocytoma and Paraganglioma.
Endocrinol Metab (Seoul)
; 36(3): 697-701, 2021 06.
Article
en En
| MEDLINE
| ID: mdl-34107605
ABSTRACT
BACKGROUND:
Pheochromocytoma and paraganglioma (PPGL) is diagnosed through biochemical confirmation of excessive catecholamines in urine and plasma. Recent technological developments have allowed us to measure urinary free metanephrines; however, the diagnostic accuracy of these new methods and the diagnostic cutoff values have not been evaluated.METHODS:
This is a retrospective study of 595 subjects, including 71 PPGL cases and 524 controls. PPGL was based on pathological confirmation. Subjects with no evidence of PPGL over 2 years were included in the control group.RESULTS:
Urinary free metanephrines yielded similar area under the curve (AUC) to urinary fractionated metanephrines and plasma free metanephrines. However, urinary free normetanephrine yielded a better AUC than did urinary fractionated normetanephrine. The optimal cutoff for urinary free metanephrine and normetanephrine corrected for urinary creatinine yielded 97.2% sensitivity and 98.1% specificity.CONCLUSION:
Urinary free metanephrines are a reliable method for diagnosing PPGL in Asian populations compared with existing biochemical methods.Palabras clave
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Paraganglioma
/
Feocromocitoma
/
Neoplasias de las Glándulas Suprarrenales
Tipo de estudio:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
Endocrinol Metab (Seoul)
Año:
2021
Tipo del documento:
Article