Precision association of lymphatic disease spread with radiation-associated toxicity in oropharyngeal squamous carcinomas.
Radiother Oncol
; 161: 152-158, 2021 08.
Article
en En
| MEDLINE
| ID: mdl-34126138
ABSTRACT
PURPOSE:
To determine whether patient similarity in terms of head and neck cancer spread through lymph nodes correlates significantly with radiation-associated toxicity. MATERIALS ANDMETHODS:
582 head and neck cancer patients received radiotherapy for oropharyngeal cancer (OPC) and had non-metastatic affected lymph nodes in the head and neck. Affected lymph nodes were segmented from pretreatment contrast-enhanced tomography scans and categorized according to consensus guidelines. Similar patients were clustered into 4 groups according to a graph-based representation of disease spread through affected lymph nodes. Correlation between dysphagia-associated symptoms and patient groups was calculated.RESULTS:
Out of 582 patients, 26% (152) experienced toxicity during a follow up evaluation 6 months after completion of radiotherapy treatment. Patient groups identified by our approach were significantly correlated with dysphagia, feeding tube, and aspiration toxicity (p < .0005).DISCUSSION:
Our results suggest that structural geometry-aware characterization of affected lymph nodes can be used to better predict radiation-associated dysphagia at time of diagnosis, and better inform treatment guidelines.CONCLUSION:
Our work successfully stratified a patient cohort into similar groups using a structural geometry, graph-encoding of affected lymph nodes in oropharyngeal cancer patients, that were predictive of late radiation-associated dysphagia and toxicity.Palabras clave
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Carcinoma de Células Escamosas
/
Neoplasias Orofaríngeas
/
Neoplasias de Cabeza y Cuello
/
Enfermedades Linfáticas
Tipo de estudio:
Guideline
/
Qualitative_research
/
Risk_factors_studies
Límite:
Humans
Idioma:
En
Revista:
Radiother Oncol
Año:
2021
Tipo del documento:
Article