Perfluorooctane sulfonate interferes with non-genomic estrogen receptor signaling pathway, inhibits ERK1/2 activation and induces apoptosis in mouse spermatocyte-derived cells.

Qu, Jianhua; Han, Yu; Zhao, Ziyan; Wu, Yuan; Lu, Ying; Chen, Gang; Jiang, Junkang; Qiu, Lianglin; Gu, Aihua; Wang, Xinru

Qu, Jianhua; Han, Yu; Zhao, Ziyan; Wu, Yuan; Lu, Ying; Chen, Gang; Jiang, Junkang; Qiu, Lianglin; Gu, Aihua; Wang, Xinru.

Afiliación

Qu J; School of Public Health, Nantong University, 9 Seyuan Road, Nantong, 226019, China. Electronic address: qjhacm@163.com.
Han Y; School of Public Health, Nantong University, 9 Seyuan Road, Nantong, 226019, China.
Zhao Z; School of Public Health, Nantong University, 9 Seyuan Road, Nantong, 226019, China.
Wu Y; Department of Medical Oncology, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, 210009, China.
Lu Y; School of Public Health, Nantong University, 9 Seyuan Road, Nantong, 226019, China.
Chen G; School of Public Health, Nantong University, 9 Seyuan Road, Nantong, 226019, China.
Jiang J; School of Public Health, Nantong University, 9 Seyuan Road, Nantong, 226019, China.
Qiu L; School of Public Health, Nantong University, 9 Seyuan Road, Nantong, 226019, China.
Gu A; Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, 211166, China.
Wang X; Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, 211166, China.

Toxicology ; 460: 152871, 2021 08.

Article en En | MEDLINE | ID: mdl-34303733

Asunto(s)

Ácidos Alcanesulfónicos/toxicidad; Apoptosis/efectos de los fármacos; Fluorocarburos/toxicidad; Sistema de Señalización de MAP Quinasas/efectos de los fármacos; Receptores de Estrógenos/antagonistas & inhibidores; Espermatocitos/efectos de los fármacos; Animales; Apoptosis/fisiología; Línea Celular; Supervivencia Celular/efectos de los fármacos; Supervivencia Celular/fisiología; Chlorocebus aethiops; Relación Dosis-Respuesta a Droga; Sistema de Señalización de MAP Quinasas/fisiología; Masculino; Ratones; Receptores de Estrógenos/metabolismo; Transducción de Señal/efectos de los fármacos; Transducción de Señal/fisiología; Espermatocitos/metabolismo

Palabras clave

ERK1/2 signaling; Estrogen receptor; Mouse spermatocyte-derived GC-2 cells; PFOS

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Texto completo: 1 Colección: 01-internacional Asunto principal: Espermatocitos / Receptores de Estrógenos / Apoptosis / Ácidos Alcanesulfónicos / Sistema de Señalización de MAP Quinasas / Fluorocarburos Límite: Animals Idioma: En Revista: Toxicology Año: 2021 Tipo del documento: Article

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