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Impact of personal genomic risk information on melanoma prevention behaviors and psychological outcomes: a randomized controlled trial.
Smit, Amelia K; Allen, Martin; Beswick, Brooke; Butow, Phyllis; Dawkins, Hugh; Dobbinson, Suzanne J; Dunlop, Kate L; Espinoza, David; Fenton, Georgina; Kanetsky, Peter A; Keogh, Louise; Kimlin, Michael G; Kirk, Judy; Law, Matthew H; Lo, Serigne; Low, Cynthia; Mann, Graham J; Reyes-Marcelino, Gillian; Morton, Rachael L; Newson, Ainsley J; Savard, Jacqueline; Trevena, Lyndal; Wordsworth, Sarah; Cust, Anne E.
Afiliación
  • Smit AK; The Daffodil Centre, The University of Sydney, a joint venture with Cancer Council NSW, NSW, Sydney, Australia.
  • Allen M; Melanoma Institute Australia, The University of Sydney, Sydney, NSW, Australia.
  • Beswick B; Electrical and Computer Engineering, University of Canterbury, Christchurch, New Zealand.
  • Butow P; The Daffodil Centre, The University of Sydney, a joint venture with Cancer Council NSW, NSW, Sydney, Australia.
  • Dawkins H; Centre for Medical Psychology and Evidence-based Decision-making, School of Psychology, The University of Sydney, Sydney, NSW, Australia.
  • Dobbinson SJ; Division of Genetics, School of Biomedical Sciences, University of Western Australia, Crawley, WA, Australia.
  • Dunlop KL; School of Medicine, The University of Notre Dame, Notre Dame, NSW, Australia.
  • Espinoza D; Cancer Council Victoria, Melbourne, VIC, Australia.
  • Fenton G; The Daffodil Centre, The University of Sydney, a joint venture with Cancer Council NSW, NSW, Sydney, Australia.
  • Kanetsky PA; NHMRC Clinical Trials Centre, The University of Sydney, Sydney, NSW, Australia.
  • Keogh L; The Daffodil Centre, The University of Sydney, a joint venture with Cancer Council NSW, NSW, Sydney, Australia.
  • Kimlin MG; H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
  • Kirk J; Melbourne School of Population and Global Health, The University of Melbourne, Parkville, VIC, Australia.
  • Law MH; Queensland University of Technology, School of Biomedical Sciences, Brisbane, QLD, Australia.
  • Lo S; Westmead Clinical School and Westmead Institute for Medical Research, Sydney Medical School, The University of Sydney, Sydney, NSW, Australia.
  • Low C; Statistical Genetics, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
  • Mann GJ; Queensland University of Technology (QUT), Brisbane, QLD, Australia.
  • Reyes-Marcelino G; Melanoma Institute Australia, The University of Sydney, Sydney, NSW, Australia.
  • Morton RL; Consumer representative, Brisbane, QLD, Australia.
  • Newson AJ; Melanoma Institute Australia, The University of Sydney, Sydney, NSW, Australia.
  • Savard J; The John Curtin School of Medical Research, ANU College of Health and Medicine, ANU, ACT, Canberra, Australia.
  • Trevena L; The Daffodil Centre, The University of Sydney, a joint venture with Cancer Council NSW, NSW, Sydney, Australia.
  • Wordsworth S; Melanoma Institute Australia, The University of Sydney, Sydney, NSW, Australia.
  • Cust AE; NHMRC Clinical Trials Centre, The University of Sydney, Sydney, NSW, Australia.
Genet Med ; 23(12): 2394-2403, 2021 12.
Article en En | MEDLINE | ID: mdl-34385669
ABSTRACT

PURPOSE:

We evaluated the impact of personal melanoma genomic risk information on sun-related behaviors and psychological outcomes.

METHODS:

In this parallel group, open, randomized controlled trial, 1,025 Australians of European ancestry without melanoma and aged 18-69 years were recruited via the Medicare database (3% consent). Participants were randomized to the intervention (n = 513; saliva sample for genetic testing, personalized melanoma risk booklet based on a 40-variant polygenic risk score, telephone-based genetic counseling, educational booklet) or control (n = 512; educational booklet). Wrist-worn ultraviolet (UV) radiation dosimeters (10-day wear) and questionnaires were administered at baseline, 1 month postintervention, and 12 months postbaseline.

RESULTS:

At 12 months, 948 (92%) participants completed dosimetry and 973 (95%) the questionnaire. For the primary outcome, there was no effect of the genomic risk intervention on objectively measured UV exposure at 12 months, irrespective of traditional risk factors. For secondary outcomes at 12 months, the intervention reduced sunburns (risk ratio 0.72, 95% confidence interval 0.54-0.96), and increased skin examinations among women. Melanoma-related worry was reduced. There was no overall impact on general psychological distress.

CONCLUSION:

Personalized genomic risk information did not influence sun exposure patterns but did improve some skin cancer prevention and early detection behaviors, suggesting it may be useful for precision prevention. There was no evidence of psychological harm.
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Texto completo: 1 Colección: 01-internacional Asunto principal: Neoplasias Cutáneas / Melanoma Tipo de estudio: Clinical_trials / Diagnostic_studies / Etiology_studies / Risk_factors_studies / Screening_studies Límite: Adolescent / Adult / Aged / Female / Humans / Middle aged País/Región como asunto: Oceania Idioma: En Revista: Genet Med Asunto de la revista: GENETICA MEDICA Año: 2021 Tipo del documento: Article País de afiliación: Australia
Texto completo
Imprimir
XML
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Buscar en Google

Texto completo: 1 Colección: 01-internacional Asunto principal: Neoplasias Cutáneas / Melanoma Tipo de estudio: Clinical_trials / Diagnostic_studies / Etiology_studies / Risk_factors_studies / Screening_studies Límite: Adolescent / Adult / Aged / Female / Humans / Middle aged País/Región como asunto: Oceania Idioma: En Revista: Genet Med Asunto de la revista: GENETICA MEDICA Año: 2021 Tipo del documento: Article País de afiliación: Australia