Impact of obesity and ovariectomy on respiratory function in female mice.
Respir Physiol Neurobiol
; 294: 103775, 2021 12.
Article
en En
| MEDLINE
| ID: mdl-34416380
ABSTRACT
Obesity and the corresponding variations in female sex hormones are associated with severe lung disease. We determined the potential effects of obesity and sex hormones in female mice by investigating changes in lung structure and respiratory function in an obesity model induced by postnatal overnutrition. Obese female mice exhibited pronounced weight gain, abdominal fat accumulation and collagen type I deposition in the airways. However, neither elastic tissue nor estrogen receptors-α/-ß were affected in obese female mice after ovariectomy or sham-operated mice. Bronchoconstriction in response to methacholine challenge in obese sham-operated mice was higher than in the obese group after ovariectomy. Our results suggest that the coexistence of obesity and ovariectomy impacted on respiratory system and airway resistance (attenuates bronchoconstriction after methacholine), on collagen I deposition and on airway estrogen ß-receptors of mice.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Trastornos Respiratorios
/
Ovariectomía
/
Resistencia de las Vías Respiratorias
/
Broncoconstricción
/
Colágeno Tipo I
/
Receptor beta de Estrógeno
/
Obesidad
Tipo de estudio:
Etiology_studies
Límite:
Animals
Idioma:
En
Revista:
Respir Physiol Neurobiol
Año:
2021
Tipo del documento:
Article
País de afiliación:
Brasil