Installation of high-affinity Siglec-1 ligand on tumor surface for macrophage-engaged tumor suppression.
Bioorg Med Chem Lett
; 50: 128328, 2021 10 15.
Article
en En
| MEDLINE
| ID: mdl-34425200
ABSTRACT
Siglecs that binds cell surface sialoglycans are a family of immunomodulatory receptors, of which, Siglec-7 expressed on natural killer (NK) cells promotes tumor immunoevation while the role of Siglec-1 expressed on macrophages on tumor development remains largely unexplored. Herein, we selectively introduced high affinity sialoside ligands of Siglec-1 and Siglec-7 to tumor cell surface via in vivo Strain-promoted Azide-Alkyne cyclization of TCCSiaα2,3-Lactose or FITCSiaα2,6-Lactose with 9-azido sialic acid (AzSia) metabolically installed on tumor cell surface. We found that TCCSiaα2,3-Lactose conjugated on tumor surface moderately inhibited tumor growth while FITCSiaα2,6-Lactose promote tumor growth. These results suggest high-affinity ligand of Siglec-1 dispalyed on tumors surface provide a new perspective for tumor immunotherapy.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Polisacáridos
/
Lectina 1 Similar a Ig de Unión al Ácido Siálico
/
Macrófagos
Límite:
Animals
Idioma:
En
Revista:
Bioorg Med Chem Lett
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2021
Tipo del documento:
Article