Mitochondrial reactive oxygen species trigger metformin-dependent antitumor immunity via activation of Nrf2/mTORC1/p62 axis in tumor-infiltrating CD8T lymphocytes.

Nishida, Mikako; Yamashita, Nahoko; Ogawa, Taisaku; Koseki, Keita; Warabi, Eiji; Ohue, Tomoyuki; Komatsu, Masaaki; Matsushita, Hirokazu; Kakimi, Kazuhiro; Kawakami, Eiryo; Shiroguchi, Katsuyuki; Udono, Heiichiro

Nishida, Mikako; Yamashita, Nahoko; Ogawa, Taisaku; Koseki, Keita; Warabi, Eiji; Ohue, Tomoyuki; Komatsu, Masaaki; Matsushita, Hirokazu; Kakimi, Kazuhiro; Kawakami, Eiryo; Shiroguchi, Katsuyuki; Udono, Heiichiro.

Afiliación

Nishida M; Immunology, Okayama University of Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan.
Yamashita N; Immunology, Okayama University of Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan.
Ogawa T; Prediction of Cell Systems Dynamics, RIKEN Center for Biosystems Dynamics Research (BDR), Osaka, Japan.
Koseki K; Medical Sciences Innovation Hub Program, RIKEN Yokohama Institute, Yokohama, Japan.
Warabi E; Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
Ohue T; Pharmaceutical Sciences, Faculty of Pharmacy, Keio University, Tokyo, Japan.
Komatsu M; Physiology, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Matsushita H; Translational Oncoimmunology, Aichi Cancer Center Research Institute, Nagoya, Japan.
Kakimi K; Immunotherapeutics, The University of Tokyo Hospital, Tokyo, Japan.
Kawakami E; Medical Sciences Innovation Hub Program, RIKEN Yokohama Institute, Yokohama, Japan.
Shiroguchi K; Artificial Intelligence Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan.
Udono H; Prediction of Cell Systems Dynamics, RIKEN Center for Biosystems Dynamics Research (BDR), Osaka, Japan.

J Immunother Cancer ; 9(9)2021 09.

Article en En | MEDLINE | ID: mdl-34531248

Asunto(s)

Linfocitos T CD8-positivos/metabolismo; Metformina/uso terapéutico; Mitocondrias/metabolismo; Factor 2 Relacionado con NF-E2/metabolismo; Animales; Línea Celular Tumoral; Femenino; Humanos; Linfocitos Infiltrantes de Tumor/metabolismo; Metformina/farmacología; Ratones; Especies Reactivas de Oxígeno; Transducción de Señal

Palabras clave

adaptive immunity; cd8-positive T-lymphocytes; immunomodulation; lymphocytes; tumor microenvironment; tumor-infiltrating

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Texto completo: 1 Colección: 01-internacional Asunto principal: Linfocitos T CD8-positivos / Factor 2 Relacionado con NF-E2 / Metformina / Mitocondrias Límite: Animals / Female / Humans Idioma: En Revista: J Immunother Cancer Año: 2021 Tipo del documento: Article País de afiliación: Japón

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