A camptothecin prodrug induces mitochondria-mediated apoptosis in cancer cells with cascade activations.
Chem Commun (Camb)
; 57(84): 11033-11036, 2021 Oct 21.
Article
en En
| MEDLINE
| ID: mdl-34608474
ABSTRACT
Mitochondria are crucial regulators of the intrinsic pathway of apoptosis. Herein, we report a photosensitizer-conjugated camptothecin (CPT)-based prodrug for combinative chemo-photodynamic treatment of solid tumors with cascade activations. Upon light irradiation, our prodrug can effectively target the mitochondria of cancer cells, generate singlet oxygen to increase the level of reactive oxygen species (ROS) and trigger ROS-responsive release of CPT, which synergistically induce mitochondrial damage and cause the apoptosis of cancer cells, therefore achieving high therapeutic efficacy for solid tumors and minimized adverse effects to normal tissues. Our prodrug holds great promise as a potent and inspiring means for cancer treatment.
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Camptotecina
/
Profármacos
/
Mitocondrias
/
Neoplasias
/
Antineoplásicos Fitogénicos
Límite:
Humans
Idioma:
En
Revista:
Chem Commun (Camb)
Asunto de la revista:
QUIMICA
Año:
2021
Tipo del documento:
Article
País de afiliación:
China