Urinary neutrophil gelatinase-associated lipocalin: Acute kidney injury in liver cirrhosis.
Clin Chim Acta
; 523: 339-347, 2021 Dec.
Article
en En
| MEDLINE
| ID: mdl-34666028
ABSTRACT
Acute kidney injury (AKI) in liver cirrhosis is associated with poor clinical outcomes including an increased long and short-term mortality. The common type of AKI observed in patients with cirrhosis are prerenal AKI (PRA), hepatorenal syndrome (HRS) and acute tubular necrosis (ATN). Despite the growing knowledge and uniform definition for the diagnosis of AKI, there are several challenges including, early diagnosis and management. Precisely differentiating the type of AKI is critical, as therapies differ significantly. In this review, we summarize AKI in liver cirrhosis, their definition, pathophysiology and deficiencies of using the existing biomarker, serum creatinine. We outline the current clinical evidence on the novel biomarker urinary neutrophil gelatinase-associated lipocalin (uNGAL) and its potential role as a biomarker in the early detection, differentiation and prognostication of AKI. This review also briefly talks about other forthcoming biomarkers which hold promise in the management of AKI in liver cirrhosis.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Lesión Renal Aguda
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Screening_studies
Límite:
Humans
Idioma:
En
Revista:
Clin Chim Acta
Año:
2021
Tipo del documento:
Article
País de afiliación:
India