Graft-versus-host disease-associated angiomatosis with striking lipomatous metaplasia.
J Cutan Pathol
; 49(4): 373-376, 2022 Apr.
Article
en En
| MEDLINE
| ID: mdl-34743349
ABSTRACT
Sclerodermatous graft-versus-host disease (GvHD) is one of the many clinicopathological variants of chronic GvHD. One of the rarest forms of this variant is GvHD-associated angiomatosis (GvHD-AA). We describe the case of a 62-year-old male with sclerodermatous GvHD who presented, in consecutive years, two different lesions that showed characteristics of GvHD-AA. The first lesion fitted perfectly with the previously known features of this rare entity. However, the second lesion was more interesting, as the angiomatoid lesion was surrounded by newly appeared adipocytes, something not previously described. The appearance of this peculiar adipose tissue may be explained as related to an important dermal atrophy, as a concomitant appearance of a lipomatous nevus and GvHD-AA, or, finally, as mature adipose tissue related to a previous inflammatory process, that is, lipomatous metaplasia. Both lesions were diagnosed as GvHD-AA, and the second one was considered to be associated with dermal lipomatous metaplasia. We also considered whether hypoxia could be related to both lesions. In the present report, we review previously published cases of GvHD-AA and discuss the different hypotheses that could explain the appearance of metaplasia associated with the second lesion.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Piel
/
Enfermedad Injerto contra Huésped
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Angiomatosis
/
Lipomatosis
Tipo de estudio:
Risk_factors_studies
Límite:
Humans
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Male
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Middle aged
Idioma:
En
Revista:
J Cutan Pathol
Año:
2022
Tipo del documento:
Article
País de afiliación:
España