Changes in the gut microbiota of morbidly obese patients after laparoscopic sleeve gastrectomy.
Future Microbiol
; 17: 5-15, 2022 01.
Article
en En
| MEDLINE
| ID: mdl-34877878
ABSTRACT
Aims:
Permanent treatment of morbid obesity with medication or diet is nearly impossible. Laparoscopic sleeve gastrectomy (LSG) is becoming a widely accepted treatment option. This study profiled and compared gut microbiota composition before and after LSG. Methods &results:
A total of 54 stool samples were collected from 27 morbidly obese individuals before and after LSG. The gut microbiota was profiled with 16S amplicon sequencing. After LSG, patients demonstrated a significant decrease (p < 0.001) in BMI and an increase in bacterial diversity. An increased Firmicutes/Bacteroidetes ratio was also noticed after LSG. The families Prevotellaceae and Veillonellaceae predominated in preoperative samples but were markedly lowered after LSG. A marked increase in Akkermansia, Alistipes, Streptococcus, Ruminococcus and Parabacteroides was observed after LSG.Conclusion:
In addition to lowering BMI, LSG remodeled gut microbiota composition.Palabras clave
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Obesidad Mórbida
/
Laparoscopía
/
Microbioma Gastrointestinal
Límite:
Humans
Idioma:
En
Revista:
Future Microbiol
Asunto de la revista:
MICROBIOLOGIA
Año:
2022
Tipo del documento:
Article
País de afiliación:
Turquía