Viral Transduction of Human Rod Opsin or Channelrhodopsin Variants to Mouse ON Bipolar Cells Does Not Impact Retinal Anatomy or Cause Measurable Death in the Targeted Cells.

Wright, Phillip; Rodgers, Jessica; Wynne, Jonathan; Bishop, Paul N; Lucas, Robert J; Milosavljevic, Nina

Wright, Phillip; Rodgers, Jessica; Wynne, Jonathan; Bishop, Paul N; Lucas, Robert J; Milosavljevic, Nina.

Afiliación

Wright P; Faculty of Biology Medicine and Health, University of Manchester, Manchester M13 9PL, UK.
Rodgers J; Faculty of Biology Medicine and Health, University of Manchester, Manchester M13 9PL, UK.
Wynne J; Faculty of Biology Medicine and Health, University of Manchester, Manchester M13 9PL, UK.
Bishop PN; Faculty of Biology Medicine and Health, University of Manchester, Manchester M13 9PL, UK.
Lucas RJ; Faculty of Biology Medicine and Health, University of Manchester, Manchester M13 9PL, UK.
Milosavljevic N; Faculty of Biology Medicine and Health, University of Manchester, Manchester M13 9PL, UK.

Int J Mol Sci ; 22(23)2021 Dec 03.

Article en En | MEDLINE | ID: mdl-34884916

Asunto(s)

Channelrhodopsins/genética; Variación Genética; Células Bipolares de la Retina/metabolismo; Opsinas de Bastones/genética; Animales; Channelrhodopsins/metabolismo; Dependovirus/genética; Humanos; Inyecciones Intravítreas; Ratones; Optogenética; Opsinas de Bastones/metabolismo; Transducción Genética

Palabras clave

ON bipolar cells; channelrhodopsin; optogenetics; rodopsin; vision restoration

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Texto completo: 1 Colección: 01-internacional Asunto principal: Variación Genética / Opsinas de Bastones / Células Bipolares de la Retina / Channelrhodopsins Límite: Animals / Humans Idioma: En Revista: Int J Mol Sci Año: 2021 Tipo del documento: Article País de afiliación: Reino Unido

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