A bis-pyridinium fullerene derivative induces apoptosis through the generation of ROS in BCR-ABL-positive leukemia cells.

Sumi, Kazuya; Tago, Kenji; Nakazawa, Yosuke; Takahashi, Kyoko; Ohe, Tomoyuki; Mashino, Tadahiko; Funakoshi-Tago, Megumi

Sumi, Kazuya; Tago, Kenji; Nakazawa, Yosuke; Takahashi, Kyoko; Ohe, Tomoyuki; Mashino, Tadahiko; Funakoshi-Tago, Megumi.

Afiliación

Sumi K; Division of Hygienic Chemistry, Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo, 105-8512, Japan.
Tago K; Division of Structural Biochemistry, Department of Biochemistry, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-shi, Tochigi-ken, 329-0498, Japan. Electronic address: ktago@jichi.ac.jp.
Nakazawa Y; Division of Hygienic Chemistry, Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo, 105-8512, Japan.
Takahashi K; Division of Pharmaceutical Sciences, Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo, 105-8512, Japan.
Ohe T; Division of Pharmaceutical Sciences, Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo, 105-8512, Japan.
Mashino T; Division of Pharmaceutical Sciences, Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo, 105-8512, Japan.
Funakoshi-Tago M; Division of Hygienic Chemistry, Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo, 105-8512, Japan. Electronic address: tago-mg@pha.keio.ac.jp.

Eur J Pharmacol ; 916: 174714, 2022 Feb 05.

Article en En | MEDLINE | ID: mdl-34953803

Asunto(s)

Antineoplásicos; Fulerenos; Leucemia Mielógena Crónica BCR-ABL Positiva; Antineoplásicos/química; Antineoplásicos/farmacología; Antineoplásicos/uso terapéutico; Apoptosis; Resistencia a Antineoplásicos; Fulerenos/química; Proteínas de Fusión bcr-abl/metabolismo; Humanos; Mesilato de Imatinib/farmacología; Células K562; Leucemia Mielógena Crónica BCR-ABL Positiva/genética; Especies Reactivas de Oxígeno/metabolismo

Palabras clave

Acute lymphocytic leukemia (ALL); BCR-ABL; Bis-pyridinium fullerene derivative (BPF); Chronic myeloid leukemia (CML); Reactive oxygen species (ROS)

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Texto completo: 1 Colección: 01-internacional Asunto principal: Leucemia Mielógena Crónica BCR-ABL Positiva / Fulerenos / Antineoplásicos Límite: Humans Idioma: En Revista: Eur J Pharmacol Año: 2022 Tipo del documento: Article País de afiliación: Japón

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