Metformin prevents methylglyoxal-induced apoptosis by suppressing oxidative stress in vitro and in vivo.

Wang, Gang; Wang, Yanan; Yang, Qinzhi; Xu, Chunrong; Zheng, Youkun; Wang, Liqun; Wu, Jianbo; Zeng, Min; Luo, Mao

Wang, Gang; Wang, Yanan; Yang, Qinzhi; Xu, Chunrong; Zheng, Youkun; Wang, Liqun; Wu, Jianbo; Zeng, Min; Luo, Mao.

Afiliación

Wang G; Collaborative Innovation Center for Prevention and Treatment of Cardiovascular Disease of Sichuan Province, Drug Discovery Research Center, Southwest Medical University, Luzhou, China.
Wang Y; Laboratory for Cardiovascular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, China.
Yang Q; School of Pharmacy, Chongqing Medical University, Chongqing, China.
Xu C; Collaborative Innovation Center for Prevention and Treatment of Cardiovascular Disease of Sichuan Province, Drug Discovery Research Center, Southwest Medical University, Luzhou, China.
Zheng Y; Laboratory for Cardiovascular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, China.
Wang L; Collaborative Innovation Center for Prevention and Treatment of Cardiovascular Disease of Sichuan Province, Drug Discovery Research Center, Southwest Medical University, Luzhou, China.
Wu J; Laboratory for Cardiovascular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, China.
Zeng M; Collaborative Innovation Center for Prevention and Treatment of Cardiovascular Disease of Sichuan Province, Drug Discovery Research Center, Southwest Medical University, Luzhou, China.
Luo M; Laboratory for Cardiovascular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, China.

Cell Death Dis ; 13(1): 29, 2022 01 10.

Article en En | MEDLINE | ID: mdl-35013107

Asunto(s)

Apoptosis/efectos de los fármacos; Metformina/farmacología; Estrés Oxidativo/efectos de los fármacos; Piruvaldehído/toxicidad; Animales; Hemo-Oxigenasa 1/metabolismo; Células Endoteliales de la Vena Umbilical Humana; Humanos; Inflamación; Metformina/administración & dosificación; Ratones; Mitocondrias/efectos de los fármacos; Factor 2 Relacionado con NF-E2/metabolismo; Fosfatidilinositol 3-Quinasas/metabolismo; Proteínas Proto-Oncogénicas c-akt/metabolismo; Piruvaldehído/administración & dosificación; Especies Reactivas de Oxígeno/metabolismo; Transducción de Señal/efectos de los fármacos; Lesiones del Sistema Vascular/inducido químicamente; Lesiones del Sistema Vascular/tratamiento farmacológico; Lesiones del Sistema Vascular/metabolismo; Lesiones del Sistema Vascular/patología

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Texto completo: 1 Colección: 01-internacional Asunto principal: Piruvaldehído / Apoptosis / Estrés Oxidativo / Metformina Límite: Animals / Humans Idioma: En Revista: Cell Death Dis Año: 2022 Tipo del documento: Article País de afiliación: China

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