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Development of Selective Phosphatidylinositol 5-Phosphate 4-Kinase γ Inhibitors with a Non-ATP-competitive, Allosteric Binding Mode.
Boffey, Helen K; Rooney, Timothy P C; Willems, Henriette M G; Edwards, Simon; Green, Christopher; Howard, Tina; Ogg, Derek; Romero, Tamara; Scott, Duncan E; Winpenny, David; Duce, James; Skidmore, John; Clarke, Jonathan H; Andrews, Stephen P.
Afiliación
  • Boffey HK; The ALBORADA Drug Discovery Institute, University of Cambridge, Island Research Building, Cambridge Biomedical Campus, Hills Road, Cambridge CB2 0AH, U.K.
  • Rooney TPC; The ALBORADA Drug Discovery Institute, University of Cambridge, Island Research Building, Cambridge Biomedical Campus, Hills Road, Cambridge CB2 0AH, U.K.
  • Willems HMG; The ALBORADA Drug Discovery Institute, University of Cambridge, Island Research Building, Cambridge Biomedical Campus, Hills Road, Cambridge CB2 0AH, U.K.
  • Edwards S; The ALBORADA Drug Discovery Institute, University of Cambridge, Island Research Building, Cambridge Biomedical Campus, Hills Road, Cambridge CB2 0AH, U.K.
  • Green C; UK Dementia Research Institute, University of Cambridge, Island Research Building, Cambridge Biomedical Campus, Hills Road, Cambridge CB2 0AH, U.K.
  • Howard T; Peak Proteins, Alderley Park, Macclesfield SK10 4TG, Cheshire, U.K.
  • Ogg D; Peak Proteins, Alderley Park, Macclesfield SK10 4TG, Cheshire, U.K.
  • Romero T; The ALBORADA Drug Discovery Institute, University of Cambridge, Island Research Building, Cambridge Biomedical Campus, Hills Road, Cambridge CB2 0AH, U.K.
  • Scott DE; The ALBORADA Drug Discovery Institute, University of Cambridge, Island Research Building, Cambridge Biomedical Campus, Hills Road, Cambridge CB2 0AH, U.K.
  • Winpenny D; The ALBORADA Drug Discovery Institute, University of Cambridge, Island Research Building, Cambridge Biomedical Campus, Hills Road, Cambridge CB2 0AH, U.K.
  • Duce J; The ALBORADA Drug Discovery Institute, University of Cambridge, Island Research Building, Cambridge Biomedical Campus, Hills Road, Cambridge CB2 0AH, U.K.
  • Skidmore J; The ALBORADA Drug Discovery Institute, University of Cambridge, Island Research Building, Cambridge Biomedical Campus, Hills Road, Cambridge CB2 0AH, U.K.
  • Clarke JH; The ALBORADA Drug Discovery Institute, University of Cambridge, Island Research Building, Cambridge Biomedical Campus, Hills Road, Cambridge CB2 0AH, U.K.
  • Andrews SP; The ALBORADA Drug Discovery Institute, University of Cambridge, Island Research Building, Cambridge Biomedical Campus, Hills Road, Cambridge CB2 0AH, U.K.
J Med Chem ; 65(4): 3359-3370, 2022 02 24.
Article en En | MEDLINE | ID: mdl-35148092
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Texto completo: 1 Colección: 01-internacional Asunto principal: Quinazolinas / Tiofenos / Adenosina Trifosfato / Fosfotransferasas (Aceptor de Grupo Alcohol) / Inhibidores de Proteínas Quinasas Límite: Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2022 Tipo del documento: Article País de afiliación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Asunto principal: Quinazolinas / Tiofenos / Adenosina Trifosfato / Fosfotransferasas (Aceptor de Grupo Alcohol) / Inhibidores de Proteínas Quinasas Límite: Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2022 Tipo del documento: Article País de afiliación: Reino Unido