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Chest CT of Lung Injury 1 Year after COVID-19 Pneumonia: The CovILD Study.
Luger, Anna K; Sonnweber, Thomas; Gruber, Leonhard; Schwabl, Christoph; Cima, Katharina; Tymoszuk, Piotr; Gerstner, Anna K; Pizzini, Alex; Sahanic, Sabina; Boehm, Anna; Coen, Maximilian; Strolz, Carola J; Wöll, Ewald; Weiss, Günter; Kirchmair, Rudolf; Feuchtner, Gudrun M; Prosch, Helmut; Tancevski, Ivan; Löffler-Ragg, Judith; Widmann, Gerlig.
Afiliación
  • Luger AK; From the Departments of Radiology (A.K.L., L.G., C.S., A.K.G., G.M.F., G.W.), Internal Medicine (T.S., K.C., P.T., A.P., S.S., A.B., M.C., G.W., R.K., I.T., J.L.R.), and Visceral, Transplant and Thoracic Surgery (C.J.S.), Medical University of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria; Dep
  • Sonnweber T; From the Departments of Radiology (A.K.L., L.G., C.S., A.K.G., G.M.F., G.W.), Internal Medicine (T.S., K.C., P.T., A.P., S.S., A.B., M.C., G.W., R.K., I.T., J.L.R.), and Visceral, Transplant and Thoracic Surgery (C.J.S.), Medical University of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria; Dep
  • Gruber L; From the Departments of Radiology (A.K.L., L.G., C.S., A.K.G., G.M.F., G.W.), Internal Medicine (T.S., K.C., P.T., A.P., S.S., A.B., M.C., G.W., R.K., I.T., J.L.R.), and Visceral, Transplant and Thoracic Surgery (C.J.S.), Medical University of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria; Dep
  • Schwabl C; From the Departments of Radiology (A.K.L., L.G., C.S., A.K.G., G.M.F., G.W.), Internal Medicine (T.S., K.C., P.T., A.P., S.S., A.B., M.C., G.W., R.K., I.T., J.L.R.), and Visceral, Transplant and Thoracic Surgery (C.J.S.), Medical University of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria; Dep
  • Cima K; From the Departments of Radiology (A.K.L., L.G., C.S., A.K.G., G.M.F., G.W.), Internal Medicine (T.S., K.C., P.T., A.P., S.S., A.B., M.C., G.W., R.K., I.T., J.L.R.), and Visceral, Transplant and Thoracic Surgery (C.J.S.), Medical University of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria; Dep
  • Tymoszuk P; From the Departments of Radiology (A.K.L., L.G., C.S., A.K.G., G.M.F., G.W.), Internal Medicine (T.S., K.C., P.T., A.P., S.S., A.B., M.C., G.W., R.K., I.T., J.L.R.), and Visceral, Transplant and Thoracic Surgery (C.J.S.), Medical University of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria; Dep
  • Gerstner AK; From the Departments of Radiology (A.K.L., L.G., C.S., A.K.G., G.M.F., G.W.), Internal Medicine (T.S., K.C., P.T., A.P., S.S., A.B., M.C., G.W., R.K., I.T., J.L.R.), and Visceral, Transplant and Thoracic Surgery (C.J.S.), Medical University of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria; Dep
  • Pizzini A; From the Departments of Radiology (A.K.L., L.G., C.S., A.K.G., G.M.F., G.W.), Internal Medicine (T.S., K.C., P.T., A.P., S.S., A.B., M.C., G.W., R.K., I.T., J.L.R.), and Visceral, Transplant and Thoracic Surgery (C.J.S.), Medical University of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria; Dep
  • Sahanic S; From the Departments of Radiology (A.K.L., L.G., C.S., A.K.G., G.M.F., G.W.), Internal Medicine (T.S., K.C., P.T., A.P., S.S., A.B., M.C., G.W., R.K., I.T., J.L.R.), and Visceral, Transplant and Thoracic Surgery (C.J.S.), Medical University of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria; Dep
  • Boehm A; From the Departments of Radiology (A.K.L., L.G., C.S., A.K.G., G.M.F., G.W.), Internal Medicine (T.S., K.C., P.T., A.P., S.S., A.B., M.C., G.W., R.K., I.T., J.L.R.), and Visceral, Transplant and Thoracic Surgery (C.J.S.), Medical University of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria; Dep
  • Coen M; From the Departments of Radiology (A.K.L., L.G., C.S., A.K.G., G.M.F., G.W.), Internal Medicine (T.S., K.C., P.T., A.P., S.S., A.B., M.C., G.W., R.K., I.T., J.L.R.), and Visceral, Transplant and Thoracic Surgery (C.J.S.), Medical University of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria; Dep
  • Strolz CJ; From the Departments of Radiology (A.K.L., L.G., C.S., A.K.G., G.M.F., G.W.), Internal Medicine (T.S., K.C., P.T., A.P., S.S., A.B., M.C., G.W., R.K., I.T., J.L.R.), and Visceral, Transplant and Thoracic Surgery (C.J.S.), Medical University of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria; Dep
  • Wöll E; From the Departments of Radiology (A.K.L., L.G., C.S., A.K.G., G.M.F., G.W.), Internal Medicine (T.S., K.C., P.T., A.P., S.S., A.B., M.C., G.W., R.K., I.T., J.L.R.), and Visceral, Transplant and Thoracic Surgery (C.J.S.), Medical University of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria; Dep
  • Weiss G; From the Departments of Radiology (A.K.L., L.G., C.S., A.K.G., G.M.F., G.W.), Internal Medicine (T.S., K.C., P.T., A.P., S.S., A.B., M.C., G.W., R.K., I.T., J.L.R.), and Visceral, Transplant and Thoracic Surgery (C.J.S.), Medical University of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria; Dep
  • Kirchmair R; From the Departments of Radiology (A.K.L., L.G., C.S., A.K.G., G.M.F., G.W.), Internal Medicine (T.S., K.C., P.T., A.P., S.S., A.B., M.C., G.W., R.K., I.T., J.L.R.), and Visceral, Transplant and Thoracic Surgery (C.J.S.), Medical University of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria; Dep
  • Feuchtner GM; From the Departments of Radiology (A.K.L., L.G., C.S., A.K.G., G.M.F., G.W.), Internal Medicine (T.S., K.C., P.T., A.P., S.S., A.B., M.C., G.W., R.K., I.T., J.L.R.), and Visceral, Transplant and Thoracic Surgery (C.J.S.), Medical University of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria; Dep
  • Prosch H; From the Departments of Radiology (A.K.L., L.G., C.S., A.K.G., G.M.F., G.W.), Internal Medicine (T.S., K.C., P.T., A.P., S.S., A.B., M.C., G.W., R.K., I.T., J.L.R.), and Visceral, Transplant and Thoracic Surgery (C.J.S.), Medical University of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria; Dep
  • Tancevski I; From the Departments of Radiology (A.K.L., L.G., C.S., A.K.G., G.M.F., G.W.), Internal Medicine (T.S., K.C., P.T., A.P., S.S., A.B., M.C., G.W., R.K., I.T., J.L.R.), and Visceral, Transplant and Thoracic Surgery (C.J.S.), Medical University of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria; Dep
  • Löffler-Ragg J; From the Departments of Radiology (A.K.L., L.G., C.S., A.K.G., G.M.F., G.W.), Internal Medicine (T.S., K.C., P.T., A.P., S.S., A.B., M.C., G.W., R.K., I.T., J.L.R.), and Visceral, Transplant and Thoracic Surgery (C.J.S.), Medical University of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria; Dep
  • Widmann G; From the Departments of Radiology (A.K.L., L.G., C.S., A.K.G., G.M.F., G.W.), Internal Medicine (T.S., K.C., P.T., A.P., S.S., A.B., M.C., G.W., R.K., I.T., J.L.R.), and Visceral, Transplant and Thoracic Surgery (C.J.S.), Medical University of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria; Dep
Radiology ; 304(2): 462-470, 2022 08.
Article en En | MEDLINE | ID: mdl-35348379
ABSTRACT
Background The long-term pulmonary sequelae of COVID-19 is not well known. Purpose To characterize patterns and rates of improvement of chest CT abnormalities 1 year after COVID-19 pneumonia. Materials and Methods This was a secondary analysis of a prospective, multicenter observational cohort study conducted from April 29 to August 12, 2020, to assess pulmonary abnormalities at chest CT approximately 2, 3, and 6 months and 1 year after onset of COVID-19 symptoms. Pulmonary findings were graded for each lung lobe using a qualitative CT severity score (CTSS) ranging from 0 (normal) to 25 (all lobes involved). The association of demographic and clinical factors with CT abnormalities after 1 year was assessed with logistic regression. The rate of change of the CTSS at follow-up CT was investigated by using the Friedmann test. Results Of 142 enrolled participants, 91 underwent a 1-year follow-up CT examination and were included in the analysis (mean age, 59 years ± 13 [SD]; 35 women [38%]). In 49 of 91 (54%) participants, CT abnormalities were observed 31 of 91 (34%) participants showed subtle subpleural reticulation, ground-glass opacities, or both, and 18 of 91 (20%) participants had extensive ground-glass opacities, reticulations, bronchial dilation, microcystic changes, or a combination thereof. At multivariable analysis, age of more than 60 years (odds ratio [OR], 5.8; 95% CI 1.7, 24; P = .009), critical COVID-19 severity (OR, 29; 95% CI 4.8, 280; P < .001), and male sex (OR, 8.9; 95% CI 2.6, 36; P < .001) were associated with persistent CT abnormalities at 1-year follow-up. Reduction of CTSS was observed in participants at subsequent follow-up CT (P < .001); during the study period, 49% (69 of 142) of participants had complete resolution of CT abnormalities. Thirty-one of 49 (63%) participants with CT abnormalities showed no further improvement after 6 months. Conclusion Long-term CT abnormalities were common 1 year after COVID-19 pneumonia. © RSNA, 2022 Online supplemental material is available for this article. See also the editorial by Leung in this issue.
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Texto completo: 1 Colección: 01-internacional Asunto principal: Lesión Pulmonar / COVID-19 Tipo de estudio: Clinical_trials / Observational_studies / Qualitative_research Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Radiology Año: 2022 Tipo del documento: Article
Texto completo
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PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Asunto principal: Lesión Pulmonar / COVID-19 Tipo de estudio: Clinical_trials / Observational_studies / Qualitative_research Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Radiology Año: 2022 Tipo del documento: Article