Your browser doesn't support javascript.
loading
Oridonin Attenuates Cisplatin-Induced Acute Kidney Injury via Inhibiting Oxidative Stress, Apoptosis, and Inflammation in Mice.
Gu, Hyemin; Gwon, Mi-Gyeong; Kim, Jong Hyun; Leem, Jaechan; Lee, Sun-Jae.
Afiliación
  • Gu H; Department of Pathology, School of Medicine, Daegu Catholic University, Daegu 42472, Republic of Korea.
  • Gwon MG; Department of Pathology, School of Medicine, Daegu Catholic University, Daegu 42472, Republic of Korea.
  • Kim JH; Department of Biochemistry, School of Medicine, Daegu Catholic University, Daegu 42472, Republic of Korea.
  • Leem J; Department of Immunology, School of Medicine, Daegu Catholic University, Daegu 42472, Republic of Korea.
  • Lee SJ; Department of Pathology, School of Medicine, Daegu Catholic University, Daegu 42472, Republic of Korea.
Biomed Res Int ; 2022: 3002962, 2022.
Article en En | MEDLINE | ID: mdl-35469348
ABSTRACT
The use of cisplatin, a chemotherapy drug, is often limited due to its renal side effects such as acute kidney injury (AKI). However, there are no validated medications to prevent or treat cisplatin-induced AKI. Oridonin is the major bioactive component of Isodon rubescens (Rabdosia rubescens) and exhibits anticancer, antioxidative, and anti-inflammatory effects. Recent studies have shown that oridonin alleviated a variety of inflammatory diseases, including renal diseases, in rodents. This study was aimed at investigating the potential renoprotective effect of oridonin on cisplatin-induced AKI. Male C57BL/6 mice were administered with cisplatin (20 mg/kg) with or without oridonin (15 mg/kg). Oridonin administration to mice after cisplatin injection attenuated renal dysfunction and histopathological changes. Upregulation of tubular injury markers was also suppressed by oridonin. Mechanistically, oridonin suppressed lipid peroxidation and reversed the decreased ratio of reduced to oxidized glutathione in cisplatin-injected mice. The increase in cisplatin-induced apoptosis was also alleviated by the compound. Moreover, oridonin inhibited cytokine overproduction and attenuated immune cell infiltration in cisplatin-injected mice. Altogether, these data demonstrated that oridonin alleviates cisplatin-induced kidney injury via inhibiting oxidative stress, apoptosis, and inflammation.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Asunto principal: Cisplatino / Lesión Renal Aguda Límite: Animals / Female / Humans / Male Idioma: En Revista: Biomed Res Int Año: 2022 Tipo del documento: Article

Texto completo: 1 Colección: 01-internacional Asunto principal: Cisplatino / Lesión Renal Aguda Límite: Animals / Female / Humans / Male Idioma: En Revista: Biomed Res Int Año: 2022 Tipo del documento: Article