An outbreak of visna-maedi in a flock of sheep in Southern Brazil.
Braz J Microbiol
; 53(3): 1723-1730, 2022 Sep.
Article
en En
| MEDLINE
| ID: mdl-35478313
ABSTRACT
Visna-maedi is a multisystemic and progressive inflammatory disease caused by a non-oncogenic retrovirus (Visna-maedi virus, VMV). An outbreak of visna-maedi occurred in Southern Brazil in sheep with clinical signs of blindness and stumbling gait. At post-mortem examination, all animals had similar lesions, including heavy non-collapsed lungs and multifocal yellow areas in the cerebral white matter, affecting mainly the periventricular region. These lesions corresponded histologically to lymphocytic interstitial pneumonia and histiocytic periventricular encephalitis surrounding areas of necrosis, in addition to significant demyelination in the brain. Serology was performed in all the sheep from the flock and 14% were seropositive for VMV. The presence of VMV was confirmed through PCR and partial sequencing of the 5'LTR. Sequencing demonstrated that the virus had 89.7 to 90.0% of nucleotide identity with VMV strains reported in the USA. This is the first description of clinical disease related to VMV in Brazil leading to economic losses. This study calls for the need to implement control measures to prevent the spread of small ruminant lentiviruses in Brazil.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Visna
/
Virus Visna-Maedi
/
Neumonía Intersticial Progresiva de los Ovinos
Límite:
Animals
País/Región como asunto:
America do sul
/
Brasil
Idioma:
En
Revista:
Braz J Microbiol
Año:
2022
Tipo del documento:
Article
País de afiliación:
Brasil