Sattahipmycin, a Hexacyclic Xanthone Produced by a Marine-Derived Streptomyces.
J Nat Prod
; 85(5): 1211-1217, 2022 05 27.
Article
en En
| MEDLINE
| ID: mdl-35512262
ABSTRACT
Sattahipmycin was isolated from the mycelium of marine-derived Streptomyces sp. GKU 257-1 by following the antibiofilm activity against E. coli NBRC 3972 throughout the purification steps. The structure of sattahipmycin was determined to be a new polycyclic xanthone related to xantholipin but lacking a dioxymethylene and a chlorinated carbon. This compound showed activity toward Gram-positive bacteria and Plasmodium falciparum, antibiofilm formation of Escherichia coli, and cytotoxicity to human cancer cell lines. Using genome sequence data, a biosynthetic pathway leading to sattahipmycin has been proposed involving an uncharacterized type II polyketide synthase biosynthetic gene cluster.
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Streptomyces
/
Xantonas
Límite:
Humans
Idioma:
En
Revista:
J Nat Prod
Año:
2022
Tipo del documento:
Article
País de afiliación:
Tailandia