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Multitarget, Selective Compound Design Yields Potent Inhibitors of a Kinetoplastid Pteridine Reductase 1.
Pöhner, Ina; Quotadamo, Antonio; Panecka-Hofman, Joanna; Luciani, Rosaria; Santucci, Matteo; Linciano, Pasquale; Landi, Giacomo; Di Pisa, Flavio; Dello Iacono, Lucia; Pozzi, Cecilia; Mangani, Stefano; Gul, Sheraz; Witt, Gesa; Ellinger, Bernhard; Kuzikov, Maria; Santarem, Nuno; Cordeiro-da-Silva, Anabela; Costi, Maria P; Venturelli, Alberto; Wade, Rebecca C.
Afiliación
  • Pöhner I; Molecular and Cellular Modeling Group, Heidelberg Institute for Theoretical Studies (HITS), D-69118 Heidelberg, Germany.
  • Quotadamo A; Faculty of Biosciences, Heidelberg University, D-69120 Heidelberg, Germany.
  • Panecka-Hofman J; Tydock Pharma srl, Strada Gherbella 294/B, 41126 Modena, Italy.
  • Luciani R; Clinical and Experimental Medicine PhD Program, University of Modena and Reggio Emilia, 41121 Modena, Italy.
  • Santucci M; Molecular and Cellular Modeling Group, Heidelberg Institute for Theoretical Studies (HITS), D-69118 Heidelberg, Germany.
  • Linciano P; Faculty of Physics, University of Warsaw, 02-093 Warsaw, Poland.
  • Landi G; Department of Life Sciences, University of Modena and Reggio Emilia, Via Campi 103, 41125 Modena, Italy.
  • Di Pisa F; Department of Life Sciences, University of Modena and Reggio Emilia, Via Campi 103, 41125 Modena, Italy.
  • Dello Iacono L; Department of Life Sciences, University of Modena and Reggio Emilia, Via Campi 103, 41125 Modena, Italy.
  • Pozzi C; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, 53100 Siena, Italy.
  • Mangani S; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, 53100 Siena, Italy.
  • Gul S; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, 53100 Siena, Italy.
  • Witt G; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, 53100 Siena, Italy.
  • Ellinger B; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, 53100 Siena, Italy.
  • Kuzikov M; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Discovery Research ScreeningPort, Schnackenburgallee 114, D-22525 Hamburg, Germany.
  • Santarem N; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Discovery Research ScreeningPort, Schnackenburgallee 114, D-22525 Hamburg, Germany.
  • Cordeiro-da-Silva A; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Discovery Research ScreeningPort, Schnackenburgallee 114, D-22525 Hamburg, Germany.
  • Costi MP; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Discovery Research ScreeningPort, Schnackenburgallee 114, D-22525 Hamburg, Germany.
  • Venturelli A; Instituto de Investigação e Inovação em Saúde, Institute for Molecular and Cell Biology, Universidade do Porto, 4200-135 Porto, Portugal.
  • Wade RC; Instituto de Investigação e Inovação em Saúde, Institute for Molecular and Cell Biology, Universidade do Porto, 4200-135 Porto, Portugal.
J Med Chem ; 65(13): 9011-9033, 2022 07 14.
Article en En | MEDLINE | ID: mdl-35675511
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Texto completo: 1 Colección: 01-internacional Asunto principal: Oxidorreductasas / Tetrahidrofolato Deshidrogenasa / Trypanosoma brucei brucei / Leishmania major Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2022 Tipo del documento: Article País de afiliación: Alemania
Texto completo
Imprimir
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Texto completo: 1 Colección: 01-internacional Asunto principal: Oxidorreductasas / Tetrahidrofolato Deshidrogenasa / Trypanosoma brucei brucei / Leishmania major Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2022 Tipo del documento: Article País de afiliación: Alemania