Small nucleolar RNAs and SNHGs in the intestinal mucosal barrier: Emerging insights and current roles.
J Adv Res
; 46: 75-85, 2023 04.
Article
en En
| MEDLINE
| ID: mdl-35700920
ABSTRACT
BACKGROUND:
Previous studies have focused on the involvement of small nucleolar RNAs (snoRNAs) and SNHGs in tumor cell proliferation, apoptosis, invasion, and metastasis via multiple pathways, including phosphatidylinositol-3-kinase/protein kinase B (PI3K/AKT), Wnt/ß catenin, and mitogen-activated protein kinase (MAPK). These molecular mechanisms affect the integrity of the intestinal mucosal barrier. AIM OF REVIEW Current evidence regarding snoRNAs and SNHGs in the context of the mucosal barrier and modulation of homeostasis is fragmented. In this review, we collate the established information on snoRNAs and SNHGs as well as discuss the major pathways affecting the mucosal barrier. KEY SCIENTIFIC CONCEPTS OF REVIEW Intestinal mucosal immunity, microflora, and the physical barrier are altered in non-neoplastic diseases such as inflammatory bowel diseases. Dysregulated snoRNAs and SNHGs may impact the intestinal mucosal barrier to promote the pathogenesis and progression of multiple diseases. SnoRNAs or SNHGs has been shown to be associated with poor disease behaviors, indicating that they may be exploited as prognostic biomarkers. Additionally, clarifying the complicated interactions between snoRNAs or SNHGs and the mucosal barrier may provide novel insights for the therapeutic treatment targeting strengthen the intestinal mucosal barrier.Palabras clave
Texto completo:
1
Colección:
01-internacional
Asunto principal:
ARN Nucleolar Pequeño
/
Neoplasias
Límite:
Humans
Idioma:
En
Revista:
J Adv Res
Año:
2023
Tipo del documento:
Article
País de afiliación:
China