Synthesis and evaluation of imidazo[1,2-a]pyrazine derivatives as small molecule G&#945;q/11 inhibitors against uveal melanoma.

Deng, Jun-Jie; Liu, Lu; Ge, Yang; Song, Zhendong; Huang, Jie; Fan, Guangjin; Xiong, Xiao-Feng

Synthesis and evaluation of imidazo[1,2-a]pyrazine derivatives as small molecule Gαq/11 inhibitors against uveal melanoma.

Deng, Jun-Jie; Liu, Lu; Ge, Yang; Song, Zhendong; Huang, Jie; Fan, Guangjin; Xiong, Xiao-Feng.

Afiliación

Deng JJ; National-Local Joint Engineering Laboratory of Druggability and New Drugs Evaluation, Guangdong Province Engineering Laboratory for Druggability and New Drugs Evaluation, School of Pharmaceutical Sciences, Sun Yat-sen University, 510006, Guangzhou, Guangdong, PR China.
Liu L; National-Local Joint Engineering Laboratory of Druggability and New Drugs Evaluation, Guangdong Province Engineering Laboratory for Druggability and New Drugs Evaluation, School of Pharmaceutical Sciences, Sun Yat-sen University, 510006, Guangzhou, Guangdong, PR China.
Ge Y; National-Local Joint Engineering Laboratory of Druggability and New Drugs Evaluation, Guangdong Province Engineering Laboratory for Druggability and New Drugs Evaluation, School of Pharmaceutical Sciences, Sun Yat-sen University, 510006, Guangzhou, Guangdong, PR China.
Song Z; National-Local Joint Engineering Laboratory of Druggability and New Drugs Evaluation, Guangdong Province Engineering Laboratory for Druggability and New Drugs Evaluation, School of Pharmaceutical Sciences, Sun Yat-sen University, 510006, Guangzhou, Guangdong, PR China.
Huang J; Guangdong Lung Cancer Institute, Guangdong Provincial Key Laboratory of Translational Medicine in Lung Cancer, Guangdong Provincial People's Hospital and Guangdong Academy of Medical Sciences, Guangzhou, 510080, China.
Fan G; National-Local Joint Engineering Laboratory of Druggability and New Drugs Evaluation, Guangdong Province Engineering Laboratory for Druggability and New Drugs Evaluation, School of Pharmaceutical Sciences, Sun Yat-sen University, 510006, Guangzhou, Guangdong, PR China.
Xiong XF; National-Local Joint Engineering Laboratory of Druggability and New Drugs Evaluation, Guangdong Province Engineering Laboratory for Druggability and New Drugs Evaluation, School of Pharmaceutical Sciences, Sun Yat-sen University, 510006, Guangzhou, Guangdong, PR China. Electronic address: xiongxf7@m

Eur J Med Chem ; 239: 114520, 2022 Sep 05.

Article en En | MEDLINE | ID: mdl-35716516

Asunto(s)

Melanoma; Neoplasias de la Úvea; Línea Celular Tumoral; Humanos; Melanoma/metabolismo; Pirazinas/farmacología; Neoplasias de la Úvea/tratamiento farmacológico; Neoplasias de la Úvea/genética; Neoplasias de la Úvea/metabolismo

Palabras clave

Antitumor; G proteins; Gαq/11 inhibitors; Uveal melanoma; imidazo[1,2-a]pyrazine

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Texto completo: 1 Colección: 01-internacional Asunto principal: Neoplasias de la Úvea / Melanoma Límite: Humans Idioma: En Revista: Eur J Med Chem Año: 2022 Tipo del documento: Article

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