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Metastatic melanoma of the heart: Retrospective cohort study and systematic review of prevalence, clinical characteristics, and outcomes.
Balinski, Alexander M; Vasbinder, Alexi L; Kerndt, Connor C; Catalan, Tonimarie C; Parry, Nathan P; Rehman, Rafey A; Blakely, Pennelope; Yeow, Raymond Y; Leja, Monika J; Lao, Christopher D; Fecher, Leslie A; Hayek, Salim S.
Afiliación
  • Balinski AM; Oakland University William Beaumont School of Medicine, Rochester, Michigan, USA.
  • Vasbinder AL; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, Michigan, USA.
  • Kerndt CC; Department of Internal Medicine, Spectrum Health/Michigan State University College of Human Medicine, Grand Rapids, Michigan, USA.
  • Catalan TC; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, Michigan, USA.
  • Parry NP; Oakland University William Beaumont School of Medicine, Rochester, Michigan, USA.
  • Rehman RA; Oakland University William Beaumont School of Medicine, Rochester, Michigan, USA.
  • Blakely P; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, Michigan, USA.
  • Yeow RY; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, Michigan, USA.
  • Leja MJ; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, Michigan, USA.
  • Lao CD; Department of Internal Medicine, Division of Hematology/Oncology, University of Michigan, Ann Arbor, Michigan, USA.
  • Fecher LA; Department of Internal Medicine, Division of Hematology/Oncology, University of Michigan, Ann Arbor, Michigan, USA.
  • Hayek SS; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, Michigan, USA.
Cancer Med ; 12(3): 2356-2367, 2023 02.
Article en En | MEDLINE | ID: mdl-35894689
ABSTRACT

BACKGROUND:

Cardiac metastasis of melanoma is rare and typically diagnosed post-mortem. Here we perform a retrospective cohort study and systematic review of patients with metastatic melanoma to characterize prevalence, clinical characteristics, and outcomes of cardiac metastasis.

METHODS:

We reviewed the electronic medical records of all outpatients with metastatic melanoma who underwent evaluation at the University of Michigan in Ann Arbor from January 2009 to January 2022, identifying patients with a clinical or histopathologic diagnosis of cardiac metastasis. We performed a systematic review of the literature to summarize the clinical characteristics and outcomes of patients with melanoma and cardiac metastasis.

RESULTS:

Overall, 23 of 1254 (1.8%) patients with metastatic melanoma were diagnosed with cardiac metastasis. Cardiac metastasis was reported in the right ventricle (65%), left ventricle (35%), and right atrium (35%). A total of 11 (48%) patients experienced at least one cardiovascular complication after the diagnosis of cardiac metastasis, the most common being arrhythmia (30%), heart failure (22%), and pericardial effusion (17%). Immunotherapy was more commonly used in patients with cardiac metastasis (80% vs 65%; p = 0.005). Mortality at 2-years post-diagnosis was higher for patients with cardiac metastasis compared to those without (59% vs 37%; p = 0.034). Progression of malignancy was the underlying cause of death of all patients.

CONCLUSIONS:

Cardiac metastasis occurs in <2% of patients with metastatic melanoma, can affect all cardiac structures, and is associated with various cardiovascular complications and high mortality.
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Texto completo: 1 Colección: 01-internacional Asunto principal: Neoplasias Cutáneas / Neoplasias Primarias Secundarias / Neoplasias Cardíacas / Melanoma Tipo de estudio: Etiology_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Límite: Humans Idioma: En Revista: Cancer Med Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Asunto principal: Neoplasias Cutáneas / Neoplasias Primarias Secundarias / Neoplasias Cardíacas / Melanoma Tipo de estudio: Etiology_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Límite: Humans Idioma: En Revista: Cancer Med Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos