Newborn body composition and child cardiovascular risk markers: a prospective multi-ethnic Asian cohort study.
Int J Epidemiol
; 51(6): 1835-1846, 2022 12 13.
Article
en En
| MEDLINE
| ID: mdl-35906917
ABSTRACT
BACKGROUND:
Early epidemiological studies have associated low birthweight with increased cardiovascular risk. We aimed to examine whether the fat and fat-free components of birthweight have differing relationships with childhood cardiovascular risk markers.METHODS:
In the Growing Up in Singapore Towards healthy Outcomes (GUSTO) cohort, air displacement plethysmography was conducted within 24 h after delivery in 290 naturally conceived singletons. We investigated associations of newborn cohort-specific standardized z-score of fat mass, fat-free mass, body fat percentage and birthweight on child (at 6 years of age) carotid intima-media thickness, pulse wave velocity, blood pressure, prehypertension/hypertension (>110/70 mmHg) and standardized systolic and diastolic blood pressure (SBP and DBP) trajectories (at 3-6 years of age), taking account of maternal education, height, tobacco exposure, parity, ethnicity, child's sex, gestational age, age at follow-up, and other maternal factors.RESULTS:
Clear inverse associations were seen for blood pressure with z-score of fat mass [SBP, ß (95% CI) -1.31 mmHg (-2.57, -0.06); DBP -0.79 mmHg (-1.74, 0.15)] and body fat percentage [SBP -1.46 mmHg (-2.73, -0.19); DBP -0.80 mmHg (-1.75, 0.16)], but not with fat-free mass [SBP 0.27 mmHg (-1.29, 1.83)]; DBP -0.14 mmHg (-1.30, 1.03)]. Being in the lowest tertile of fat mass or body fat percentage was associated with higher blood pressure trajectories and prehypertension/hypertension risk [OR (95% CI), fat mass 4.23 (1.41, 12.68); body fat percentage 3.22 (1.09, 9.53)] without concomitantly higher overweight/obesity risk.CONCLUSIONS:
At birth, low adiposity was associated with increased childhood blood pressure. Low newborn adiposity might serve as a marker of poor fetal growth or suboptimal intrauterine conditions associated with hypertension risk later in life.Palabras clave
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Enfermedades Cardiovasculares
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Prehipertensión
/
Hipertensión
Tipo de estudio:
Etiology_studies
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Observational_studies
/
Risk_factors_studies
Límite:
Child
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Child, preschool
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Female
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Humans
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Newborn
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Pregnancy
Idioma:
En
Revista:
Int J Epidemiol
Año:
2022
Tipo del documento:
Article
País de afiliación:
Singapur