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Biophysical and pharmacokinetic characterization of a small-molecule inhibitor of RUNX1/ETO tetramerization with anti-leukemic effects.
Gopalswamy, Mohanraj; Kroeger, Tobias; Bickel, David; Frieg, Benedikt; Akter, Shahina; Schott-Verdugo, Stephan; Viegas, Aldino; Pauly, Thomas; Mayer, Manuela; Przibilla, Julia; Reiners, Jens; Nagel-Steger, Luitgard; Smits, Sander H J; Groth, Georg; Etzkorn, Manuel; Gohlke, Holger.
Afiliación
  • Gopalswamy M; Institute for Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Universitätsstr. 1, 40225, Düsseldorf, Germany.
  • Kroeger T; Institute for Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Universitätsstr. 1, 40225, Düsseldorf, Germany.
  • Bickel D; Institute for Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Universitätsstr. 1, 40225, Düsseldorf, Germany.
  • Frieg B; Institute of Biological Information Processing (IBI-7: Structural Biochemistry), Forschungszentrum Jülich GmbH, Wilhelm-Johnen-Str, 52425, Jülich, Germany.
  • Akter S; Institute for Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Universitätsstr. 1, 40225, Düsseldorf, Germany.
  • Schott-Verdugo S; Institute for Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Universitätsstr. 1, 40225, Düsseldorf, Germany.
  • Viegas A; Institute of Biological Information Processing (IBI-7: Structural Biochemistry), Forschungszentrum Jülich GmbH, Wilhelm-Johnen-Str, 52425, Jülich, Germany.
  • Pauly T; John von Neumann Institute for Computing (NIC), Jülich Supercomputing Centre (JSC), Institute of Bio- and Geosciences (IBG-4: Bioinformatics), Forschungszentrum Jülich GmbH, Wilhelm-Johnen-Str, 52425, Jülich, Germany.
  • Mayer M; Institute for Physical Biology, Heinrich Heine University Düsseldorf, Universitätsstr. 1, 40225, Düsseldorf, Germany.
  • Przibilla J; UCIBIO, Chemistry Department, Faculty of Sciences and Technology, NOVA University of Lisbon, 2829-516, Caparica, Portugal.
  • Reiners J; Institute of Biological Information Processing (IBI-7: Structural Biochemistry), Forschungszentrum Jülich GmbH, Wilhelm-Johnen-Str, 52425, Jülich, Germany.
  • Nagel-Steger L; Institute for Physical Biology, Heinrich Heine University Düsseldorf, Universitätsstr. 1, 40225, Düsseldorf, Germany.
  • Smits SHJ; Pharmacelsus GmbH, Science Park 2, 66123, Saarbrücken, Germany.
  • Groth G; Pharmacelsus GmbH, Science Park 2, 66123, Saarbrücken, Germany.
  • Etzkorn M; Institute of Biochemistry and Center for Structural Studies, Heinrich Heine University Düsseldorf, Universitätsstr. 1, 40225, Düsseldorf, Germany.
  • Gohlke H; Institute of Biological Information Processing (IBI-7: Structural Biochemistry), Forschungszentrum Jülich GmbH, Wilhelm-Johnen-Str, 52425, Jülich, Germany.
Sci Rep ; 12(1): 14158, 2022 08 19.
Article en En | MEDLINE | ID: mdl-35986043
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Texto completo: 1 Colección: 01-internacional Asunto principal: Leucemia Mieloide Aguda / Subunidad alfa 2 del Factor de Unión al Sitio Principal Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Sci Rep Año: 2022 Tipo del documento: Article País de afiliación: Alemania
Texto completo
Imprimir
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Texto completo: 1 Colección: 01-internacional Asunto principal: Leucemia Mieloide Aguda / Subunidad alfa 2 del Factor de Unión al Sitio Principal Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Sci Rep Año: 2022 Tipo del documento: Article País de afiliación: Alemania