Magnolol Suppresses ERK/NF-κB Signaling and Triggers Apoptosis Through Extrinsic/Intrinsic Pathways in Osteosarcoma.
Anticancer Res
; 42(9): 4403-4410, 2022 Sep.
Article
en En
| MEDLINE
| ID: mdl-36039427
ABSTRACT
BACKGROUND/AIM:
Osteosarcoma is an aggressive primary malignant bone tumor that occurs in childhood. Although the diagnostic and treatment options have been improved, osteosarcoma confers poor prognosis. Magnolol, an active component of Magnoliae officinalis cortex, has been widely applied in herb medicine and has been shown to have multiple pharmacological activities. However, whether magnolol possesses anti-osteosarcoma capacity remains unknown. MATERIALS ANDMETHODS:
We examined magnolol is cytotoxicity, and whether it regulates apoptosis and oncogene expression using MTT, flow cytometry and Western blotting assays in osteosarcoma cells.RESULTS:
Magnolol exerted toxicity towards U-2 OS cells by inducing intrinsic/extrinsic apoptosis pathways. Additionally, treatment of U-2 OS cells with magnolol inhibited MAPK1 mitogen-activated protein kinase 1 (ERK)/Nuclear factor kappa B (NF-B) signaling involved in tumor progression and reduced the expression of anti-apoptotic and metastasis-associated genes.CONCLUSION:
Magnolol may induce apoptosis and inactivate ERK/NF-B signal transduction in osteosarcoma cells.Palabras clave
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Neoplasias Óseas
/
Osteosarcoma
/
Lignanos
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
Anticancer Res
Año:
2022
Tipo del documento:
Article