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High-throughput T cell receptor engineering by functional screening identifies candidates with enhanced potency and specificity.
Vazquez-Lombardi, Rodrigo; Jung, Johanna S; Schlatter, Fabrice S; Mei, Anna; Mantuano, Natalia Rodrigues; Bieberich, Florian; Hong, Kai-Lin; Kucharczyk, Jakub; Kapetanovic, Edo; Aznauryan, Erik; Weber, Cédric R; Zippelius, Alfred; Läubli, Heinz; Reddy, Sai T.
Afiliación
  • Vazquez-Lombardi R; Department of Biosystems Science and Engineering, ETH Zurich, Mattenstrasse 26, 4058 Basel, Switzerland; Engimmune Therapeutics AG, Hegenheimermattweg 167A, 4123 Allschwil, Switzerland. Electronic address: rodrigo.vl@engimmune.com.
  • Jung JS; Department of Biosystems Science and Engineering, ETH Zurich, Mattenstrasse 26, 4058 Basel, Switzerland.
  • Schlatter FS; Department of Biosystems Science and Engineering, ETH Zurich, Mattenstrasse 26, 4058 Basel, Switzerland.
  • Mei A; Department of Biosystems Science and Engineering, ETH Zurich, Mattenstrasse 26, 4058 Basel, Switzerland.
  • Mantuano NR; Department of Biomedicine, Universitätsspital Basel, Basel, Switzerland.
  • Bieberich F; Department of Biosystems Science and Engineering, ETH Zurich, Mattenstrasse 26, 4058 Basel, Switzerland.
  • Hong KL; Department of Biosystems Science and Engineering, ETH Zurich, Mattenstrasse 26, 4058 Basel, Switzerland.
  • Kucharczyk J; Department of Biosystems Science and Engineering, ETH Zurich, Mattenstrasse 26, 4058 Basel, Switzerland.
  • Kapetanovic E; Department of Biosystems Science and Engineering, ETH Zurich, Mattenstrasse 26, 4058 Basel, Switzerland.
  • Aznauryan E; Department of Biosystems Science and Engineering, ETH Zurich, Mattenstrasse 26, 4058 Basel, Switzerland.
  • Weber CR; Department of Biosystems Science and Engineering, ETH Zurich, Mattenstrasse 26, 4058 Basel, Switzerland.
  • Zippelius A; Department of Biomedicine, Universitätsspital Basel, Basel, Switzerland.
  • Läubli H; Department of Biomedicine, Universitätsspital Basel, Basel, Switzerland.
  • Reddy ST; Department of Biosystems Science and Engineering, ETH Zurich, Mattenstrasse 26, 4058 Basel, Switzerland. Electronic address: sai.reddy@ethz.ch.
Immunity ; 55(10): 1953-1966.e10, 2022 10 11.
Article en En | MEDLINE | ID: mdl-36174557
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Texto completo: 1 Colección: 01-internacional Asunto principal: Receptores de Antígenos de Linfocitos T / Inmunoterapia Adoptiva Tipo de estudio: Diagnostic_studies / Screening_studies Límite: Humans Idioma: En Revista: Immunity Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2022 Tipo del documento: Article
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Texto completo: 1 Colección: 01-internacional Asunto principal: Receptores de Antígenos de Linfocitos T / Inmunoterapia Adoptiva Tipo de estudio: Diagnostic_studies / Screening_studies Límite: Humans Idioma: En Revista: Immunity Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2022 Tipo del documento: Article