[Diagnostic Value of CYFRA 21-1 Measurement in Fine-Needle Aspiration Washouts for Detection of Axillary Recurrence in Postoperative Breast Cancer Patients]. / ì ë°©ì ìì í ì¡ì림íì ì¬ë° ì§ë¨ì ìì´ìì 미ì¸ì¹¨ì¸ì²ì¡ CYFRA 21-1ì ì§ë¨ì ê°ì¹.
Taehan Yongsang Uihakhoe Chi
; 81(1): 147-156, 2020 Jan.
Article
en Ko
| MEDLINE
| ID: mdl-36238108
ABSTRACT
Purpose:
The objective of this study was to evaluate the diagnostic value and threshold levels of cytokeratin fragment 21-1 (CYFRA 21-1) in fine-needle aspiration (FNA) washouts for detection of lymph node (LN) recurrence in postoperative breast cancer patients. Materials andMethods:
FNA cytological assessments and CYFRA 21-1 measurement in FNA washouts were performed for 64 axillary LNs suspicious for recurrence in 64 post-operative breast cancer patients. Final diagnosis was made on the basis of FNA cytology and follow-up data over at least 2 years. The concentration of CYFRA 21-1 was compared between recurrent LNs and benign LNs. Diagnostic performance and cut-off value were evaluated using a receiver operating characteristic curve.Results:
Regardless of the non-diagnostic results, the median concentration of CYFRA 21-1 in recurrent LNs was significantly higher than that in benign LNs (p < 0.001). The optimal diagnostic cut-off value was 1.6 ng/mL. The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of CYFRA 21-1 for LN recurrence were 90.9%, 100%, 100%, 98.1%, and 98.4%, respectively.Conclusion:
Measurement of CYFRA 21-1 concentration from ultrasound-guided FNA biopsy aspirates showed excellent diagnostic performance with a cut-off value of 1.6 ng/mL. These results indicate that measurement of CYFRA 21-1 concentration in FNA washouts is useful for the diagnosis of axillary LN recurrence in post-operative breast cancer patients.
Texto completo:
1
Colección:
01-internacional
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
Idioma:
Ko
Revista:
Taehan Yongsang Uihakhoe Chi
Año:
2020
Tipo del documento:
Article