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The anticancer human mTOR inhibitor sapanisertib potently inhibits multiple Plasmodium kinases and life cycle stages.
Arendse, Lauren B; Murithi, James M; Qahash, Tarrick; Pasaje, Charisse Flerida A; Godoy, Luiz C; Dey, Sumanta; Gibhard, Liezl; Ghidelli-Disse, Sonja; Drewes, Gerard; Bantscheff, Marcus; Lafuente-Monasterio, Maria J; Fienberg, Stephen; Wambua, Lynn; Gachuhi, Samuel; Coertzen, Dina; van der Watt, Mariëtte; Reader, Janette; Aswat, Ayesha S; Erlank, Erica; Venter, Nelius; Mittal, Nimisha; Luth, Madeline R; Ottilie, Sabine; Winzeler, Elizabeth A; Koekemoer, Lizette L; Birkholtz, Lyn-Marie; Niles, Jacquin C; Llinás, Manuel; Fidock, David A; Chibale, Kelly.
Afiliación
  • Arendse LB; Drug Discovery and Development Centre (H3D), University of Cape Town, Rondebosch, Cape Town 7701, South Africa.
  • Murithi JM; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, Cape Town 7925, South Africa.
  • Qahash T; South African Medical Research Council Drug Discovery and Development Research Unit, University of Cape Town, Rondebosch, Cape Town 7701, South Africa.
  • Pasaje CFA; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY 10032, USA.
  • Godoy LC; Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA 16802, USA.
  • Dey S; Huck Center for Malaria Research, Pennsylvania State University, University Park, PA 16802, USA.
  • Gibhard L; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Ghidelli-Disse S; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Drewes G; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Bantscheff M; Drug Discovery and Development Centre (H3D), University of Cape Town, Rondebosch, Cape Town 7701, South Africa.
  • Lafuente-Monasterio MJ; Cellzome GmbH, a GSK Company, Heidelberg 69117, Germany.
  • Fienberg S; Cellzome GmbH, a GSK Company, Heidelberg 69117, Germany.
  • Wambua L; Cellzome GmbH, a GSK Company, Heidelberg 69117, Germany.
  • Gachuhi S; Tres Cantos Medicines Development Campus-Diseases of the Developing World, GlaxoSmithKline, Tres Cantos, Madrid 28760, Spain.
  • Coertzen D; Drug Discovery and Development Centre (H3D), University of Cape Town, Rondebosch, Cape Town 7701, South Africa.
  • van der Watt M; Department of Chemistry, University of Cape Town, Rondebosch, Cape Town 7701, South Africa.
  • Reader J; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, Cape Town 7925, South Africa.
  • Aswat AS; Department of Chemistry, University of Cape Town, Rondebosch, Cape Town 7701, South Africa.
  • Erlank E; Department of Chemistry, University of Cape Town, Rondebosch, Cape Town 7701, South Africa.
  • Venter N; Department of Biochemistry, Genetics and Microbiology, Institute for Sustainable Malaria Control, University of Pretoria, Hatfield 0028, South Africa.
  • Mittal N; Department of Biochemistry, Genetics and Microbiology, Institute for Sustainable Malaria Control, University of Pretoria, Hatfield 0028, South Africa.
  • Luth MR; Department of Biochemistry, Genetics and Microbiology, Institute for Sustainable Malaria Control, University of Pretoria, Hatfield 0028, South Africa.
  • Ottilie S; Wits Research Institute for Malaria, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg 2193, South Africa.
  • Winzeler EA; Centre for Emerging Zoonotic and Parasitic Diseases, National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg 2193, South Africa.
  • Koekemoer LL; Wits Research Institute for Malaria, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg 2193, South Africa.
  • Birkholtz LM; Centre for Emerging Zoonotic and Parasitic Diseases, National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg 2193, South Africa.
  • Niles JC; Wits Research Institute for Malaria, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg 2193, South Africa.
  • Llinás M; Centre for Emerging Zoonotic and Parasitic Diseases, National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg 2193, South Africa.
  • Fidock DA; School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
  • Chibale K; School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
Sci Transl Med ; 14(667): eabo7219, 2022 10 19.
Article en En | MEDLINE | ID: mdl-36260689
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Texto completo: 1 Colección: 01-internacional Asunto principal: Plasmodium / Antimaláricos Límite: Animals / Humans Idioma: En Revista: Sci Transl Med Asunto de la revista: CIENCIA / MEDICINA Año: 2022 Tipo del documento: Article País de afiliación: Sudáfrica
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Asunto principal: Plasmodium / Antimaláricos Límite: Animals / Humans Idioma: En Revista: Sci Transl Med Asunto de la revista: CIENCIA / MEDICINA Año: 2022 Tipo del documento: Article País de afiliación: Sudáfrica