Synthesis and in vitro biological evaluation of 3-ethyl-1,5-naphthyridin-2(1H)-one derivatives as potent PARP-1 selective inhibitors and PARP-1 DNA trappers.

Ren, Junkang; Quan, Xu; Liu, Ying; Li, Jiani; Zhang, Xiaoyu; Li, Zhiyu; Zhang, Xiaomeng

Ren, Junkang; Quan, Xu; Liu, Ying; Li, Jiani; Zhang, Xiaoyu; Li, Zhiyu; Zhang, Xiaomeng.

Afiliación

Ren J; School of Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu 210009, China; R &D Center, Nanjing Sanhome Pharmaceutical Co. Ltd., Nanjing, Jiangsu 211135, China.
Quan X; R &D Center, Nanjing Sanhome Pharmaceutical Co. Ltd., Nanjing, Jiangsu 211135, China.
Liu Y; School of Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu 210009, China; R &D Center, Nanjing Sanhome Pharmaceutical Co. Ltd., Nanjing, Jiangsu 211135, China.
Li J; R &D Center, Nanjing Sanhome Pharmaceutical Co. Ltd., Nanjing, Jiangsu 211135, China.
Zhang X; R &D Center, Nanjing Sanhome Pharmaceutical Co. Ltd., Nanjing, Jiangsu 211135, China.
Li Z; School of Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu 210009, China. Electronic address: zhiyuli@cpu.edu.cn.
Zhang X; R &D Center, Nanjing Sanhome Pharmaceutical Co. Ltd., Nanjing, Jiangsu 211135, China. Electronic address: zhangxm@sanhome.com.

Bioorg Med Chem Lett ; 78: 129046, 2022 12 15.

Article en En | MEDLINE | ID: mdl-36343904

Asunto(s)

ADN; Inhibidores de Poli(ADP-Ribosa) Polimerasas; Inhibidores de Poli(ADP-Ribosa) Polimerasas/farmacología

Palabras clave

Antitumor; PARP DNA Trapping; PARP-1; Selectivity

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Texto completo: 1 Colección: 01-internacional Asunto principal: ADN / Inhibidores de Poli(ADP-Ribosa) Polimerasas Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2022 Tipo del documento: Article País de afiliación: China

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