Nuclear Morphological Abnormalities in Cancer: A Search for Unifying Mechanisms.
Results Probl Cell Differ
; 70: 443-467, 2022.
Article
en En
| MEDLINE
| ID: mdl-36348118
ABSTRACT
Irregularities in nuclear shape and/or alterations to nuclear size are a hallmark of malignancy in a broad range of cancer types. Though these abnormalities are commonly used for diagnostic purposes and are often used to assess cancer progression in the clinic, the mechanisms through which they occur are not well understood. Nuclear size alterations in cancer could potentially arise from aneuploidy, changes in osmotic coupling with the cytoplasm, and perturbations to nucleocytoplasmic transport. Nuclear shape changes may occur due to alterations to cell-generated mechanical stresses and/or alterations to nuclear structural components, which balance those stresses, such as the nuclear lamina and chromatin. A better understanding of the mechanisms underlying abnormal nuclear morphology and size may allow the development of new therapeutics to target nuclear aberrations in cancer.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Núcleo Celular
/
Neoplasias
Límite:
Humans
Idioma:
En
Revista:
Results Probl Cell Differ
Año:
2022
Tipo del documento:
Article
País de afiliación:
Estados Unidos