New Angucycline Glycosides from a Marine-Derived Bacterium Streptomyces ardesiacus.
Int J Mol Sci
; 23(22)2022 Nov 09.
Article
en En
| MEDLINE
| ID: mdl-36430256
ABSTRACT
Chemical investigation of the ethyl acetate extract from the culture broth of the marine-derived actinobacterium Streptomyces ardesiacus 156VN-095 led to the isolation of three hitherto undescribed angucycline glycosides, including urdamycins W and X (1 and 2) and grincamycin U (9), as well as their seven known congeners. The structures of the new compounds were elucidated by means of spectroscopic methods (HRESIMS, 1D and 2 D NMR) and comparison of their experimental data with literature values. Compounds 1-3 and 9 were evaluated for their anti-Gram-positive bacterial effect and cytotoxicity against six cancer cell lines. Compound 1 displayed significant cytotoxicity against all the tested cell lines with GI50 values of 0.019-0.104 µM. Collectively, these findings highlight the potential of angucycline glycosides as leading structures for the development of new anti-cancer drugs.
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1
Colección:
01-internacional
Asunto principal:
Streptomyces
Idioma:
En
Revista:
Int J Mol Sci
Año:
2022
Tipo del documento:
Article