Upregulation of the EGFR/MEK1/MAPK1/2 signaling axis as a mechanism of resistance to antiestrogen­induced BimEL dependent apoptosis in ER<sup>+</sup> breast cancer cells.

Hagan, Mackenzie L; Mander, Suchreet; Joseph, Carol; McGrath, Michael; Barrett, Amanda; Lewis, Allison; Hill, William D; Browning, Darren; McGee-Lawrence, Meghan E; Cai, Haifeng; Liu, Kebin; Barrett, John T; Gewirtz, David A; Thangaraju, Muthusamy; Schoenlein, Patricia V

Upregulation of the EGFR/MEK1/MAPK1/2 signaling axis as a mechanism of resistance to antiestrogeninduced BimEL dependent apoptosis in ER⁺ breast cancer cells.

Hagan, Mackenzie L; Mander, Suchreet; Joseph, Carol; McGrath, Michael; Barrett, Amanda; Lewis, Allison; Hill, William D; Browning, Darren; McGee-Lawrence, Meghan E; Cai, Haifeng; Liu, Kebin; Barrett, John T; Gewirtz, David A; Thangaraju, Muthusamy; Schoenlein, Patricia V.

Afiliación

Hagan ML; Department of Cellular Biology and Anatomy, Augusta University, Augusta, GA 30912, USA.
Mander S; Department of Cellular Biology and Anatomy, Augusta University, Augusta, GA 30912, USA.
Joseph C; Department of Cellular Biology and Anatomy, Augusta University, Augusta, GA 30912, USA.
McGrath M; Department of Cellular Biology and Anatomy, Augusta University, Augusta, GA 30912, USA.
Barrett A; Department of Pathology, Augusta University, Augusta, GA 30912, USA.
Lewis A; Department of Cellular Biology and Anatomy, Augusta University, Augusta, GA 30912, USA.
Hill WD; Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.
Browning D; Medical College of Georgia Cancer Center, Augusta University, Augusta, GA 30912, USA.
McGee-Lawrence ME; Department of Cellular Biology and Anatomy, Augusta University, Augusta, GA 30912, USA.
Cai H; Department of Cellular Biology and Anatomy, Augusta University, Augusta, GA 30912, USA.
Liu K; Medical College of Georgia Cancer Center, Augusta University, Augusta, GA 30912, USA.
Barrett JT; Medical College of Georgia Cancer Center, Augusta University, Augusta, GA 30912, USA.
Gewirtz DA; Department of Pharmacology and Toxicology, Massey Cancer Center, Richmond, VA 23298, USA.
Thangaraju M; Department of Cellular Biology and Anatomy, Augusta University, Augusta, GA 30912, USA.
Schoenlein PV; Department of Cellular Biology and Anatomy, Augusta University, Augusta, GA 30912, USA.

Int J Oncol ; 62(2)2023 Feb.

Article en En | MEDLINE | ID: mdl-36524361

Asunto(s)

Apoptosis; Neoplasias de la Mama; Resistencia a Antineoplásicos; Moduladores de los Receptores de Estrógeno; Femenino; Humanos; Apoptosis/efectos de los fármacos; Proteína 11 Similar a Bcl2/efectos de los fármacos; Proteína 11 Similar a Bcl2/metabolismo; Neoplasias de la Mama/tratamiento farmacológico; Neoplasias de la Mama/genética; Neoplasias de la Mama/metabolismo; Línea Celular Tumoral; Resistencia a Antineoplásicos/fisiología; Receptores ErbB/genética; Receptores ErbB/metabolismo; Moduladores de los Receptores de Estrógeno/farmacología; Moduladores de los Receptores de Estrógeno/uso terapéutico; Proteína Quinasa 1 Activada por Mitógenos/genética; Proteína Quinasa 1 Activada por Mitógenos/metabolismo; Regulación hacia Arriba; Transducción de Señal

Palabras clave

BimEL; EGFR; MEK1/MAPK1/2 inhibitors; antiestrogen; antiestrogen resistance; antiprogestin; apoptosis; breast cancer; prosurvival autophagy; senescence

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Texto completo: 1 Colección: 01-internacional Asunto principal: Neoplasias de la Mama / Apoptosis / Resistencia a Antineoplásicos / Moduladores de los Receptores de Estrógeno Tipo de estudio: Prognostic_studies Límite: Female / Humans Idioma: En Revista: Int J Oncol Asunto de la revista: NEOPLASIAS Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos

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