Cryptic resolution sites in the vector plasmid lead to the heterogeneities in the rAAV vectors.

Zhang, Junping; Chrzanowski, Matthew; Frabutt, Dylan A; Lam, Anh K; Mulcrone, Patrick L; Li, Lei; Konkle, Barbara A; Miao, Carol H; Xiao, Weidong

Zhang, Junping; Chrzanowski, Matthew; Frabutt, Dylan A; Lam, Anh K; Mulcrone, Patrick L; Li, Lei; Konkle, Barbara A; Miao, Carol H; Xiao, Weidong.

Afiliación

Zhang J; Herman B Wells Center for Pediatric Research, Indiana University, Indianapolis, Indiana, USA.
Chrzanowski M; Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania, USA.
Frabutt DA; Herman B Wells Center for Pediatric Research, Indiana University, Indianapolis, Indiana, USA.
Lam AK; Herman B Wells Center for Pediatric Research, Indiana University, Indianapolis, Indiana, USA.
Mulcrone PL; Herman B Wells Center for Pediatric Research, Indiana University, Indianapolis, Indiana, USA.
Li L; Department of Chemistry, Georgia State University, Atlanta, Georgia, USA.
Konkle BA; Bloodworks Northwest, Seattle, Washington, USA.
Miao CH; Center for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, Washington, USA.
Xiao W; Herman B Wells Center for Pediatric Research, Indiana University, Indianapolis, Indiana, USA.

J Med Virol ; 95(1): e28433, 2023 01.

Article en En | MEDLINE | ID: mdl-36571262

Asunto(s)

ADN Viral; Vectores Genéticos; Humanos; Vectores Genéticos/genética; Plásmidos/genética; ADN Viral/genética; Dependovirus/genética

Palabras clave

cryptic resolution; heterogeneity; rAAV; single ITR

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Texto completo: 1 Colección: 01-internacional Asunto principal: ADN Viral / Vectores Genéticos Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: J Med Virol Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos

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