Humanization of the Shark V<sub>NAR</sub> Single Domain Antibody Using CDR Grafting.

Zhang, Yi-Fan; Sun, Yaping; Hong, Jessica; Ho, Mitchell

Humanization of the Shark V_NAR Single Domain Antibody Using CDR Grafting.

Zhang, Yi-Fan; Sun, Yaping; Hong, Jessica; Ho, Mitchell.

Afiliación

Zhang YF; Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland.
Sun Y; Antibody Engineering Program, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland.
Hong J; Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland.
Ho M; Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland.

Curr Protoc ; 3(1): e630, 2023 Jan.

Article en En | MEDLINE | ID: mdl-36594750

Asunto(s)

Tiburones; Anticuerpos de Dominio Único; Animales; Humanos; Regiones Determinantes de Complementariedad/química; Antígenos; Receptores de Antígenos/química; Mamíferos

Palabras clave

Alphafold model; CDR grafting; humanization; shark VNAR CDR; shark VNAR antigen contacting residues; shark VNAR single domain antibody

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Texto completo: 1 Colección: 01-internacional Asunto principal: Tiburones / Anticuerpos de Dominio Único Tipo de estudio: Guideline / Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Curr Protoc Año: 2023 Tipo del documento: Article

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