CYX-5, a G-protein biassed MOP receptor agonist, DOP receptor antagonist and KOP receptor agonist, evokes constipation but not respiratory depression relative to morphine in rats.

Imam, Mohammad Zafar; Kuo, Andy; Ghassabian, Sussan; Cai, Yunxin; Qin, Yajuan; Li, Tingyou; Smith, Maree T

Imam, Mohammad Zafar; Kuo, Andy; Ghassabian, Sussan; Cai, Yunxin; Qin, Yajuan; Li, Tingyou; Smith, Maree T.

Afiliación

Imam MZ; School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, St Lucia Campus, Brisbane, QLD, 4072, Australia.
Kuo A; School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, St Lucia Campus, Brisbane, QLD, 4072, Australia.
Ghassabian S; School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, St Lucia Campus, Brisbane, QLD, 4072, Australia.
Cai Y; School of Pharmacy, Nanjing Medical University, Nanjing, Jiangsu, China.
Qin Y; School of Pharmacy, Nanjing Medical University, Nanjing, Jiangsu, China.
Li T; School of Pharmacy, Nanjing Medical University, Nanjing, Jiangsu, China. l_tingyou@njmu.edu.au.
Smith MT; School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, St Lucia Campus, Brisbane, QLD, 4072, Australia. maree.smith@uq.edu.au.

Pharmacol Rep ; 75(3): 634-646, 2023 Jun.

Article en En | MEDLINE | ID: mdl-36637684

Asunto(s)

Estreñimiento; Morfina; Receptores Opioides delta; Insuficiencia Respiratoria; Animales; Masculino; Ratas; Analgésicos Opioides/efectos adversos; Aceite de Ricino/efectos adversos; Estreñimiento/inducido químicamente; Estreñimiento/tratamiento farmacológico; Diarrea/tratamiento farmacológico; Proteínas de Unión al GTP; Morfina/efectos adversos; Antagonistas de Narcóticos/farmacología; Ratas Sprague-Dawley; Receptores Opioides delta/agonistas; Receptores Opioides mu/agonistas; Insuficiencia Respiratoria/inducido químicamente

Palabras clave

CYX-5; Castor oil-induced diarrhoea; Charcoal meal; Gastrointestinal motility; Hypercapnia; Intracerebroventricular (icv); Minute ventilation; Warm water tail flick test; Whole body plethysmography

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Texto completo: 1 Colección: 01-internacional Asunto principal: Insuficiencia Respiratoria / Receptores Opioides delta / Estreñimiento / Morfina Límite: Animals Idioma: En Revista: Pharmacol Rep Asunto de la revista: FARMACOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Australia

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