Nickel-Catalyzed Reductive Dicarbofunctionalizations of Alkenes for the Synthesis of Difluorocarbonyl Oxindoles and Isoquinoline-1,3-diones.
J Org Chem
; 88(8): 4995-5006, 2023 Apr 21.
Article
en En
| MEDLINE
| ID: mdl-36745403
ABSTRACT
A novel and efficient strategy for the construction of difluorocarbonyl-oxindole and difluorocarbonyl-isoquinoline-1,3-dione derivatives involving nickel-catalyzed intramolecular Heck-type cyclizations followed by intermolecular cross-couplings has been developed. This approach features high functional group tolerance, broad substrate scope, and operational simplicity under mild conditions, thus providing a new method for the rapid difluorocarbonyl-functionalization of alkenes to construct the structurally diversified five- and six-membered heterocycles.
Texto completo:
1
Colección:
01-internacional
Idioma:
En
Revista:
J Org Chem
Año:
2023
Tipo del documento:
Article
País de afiliación:
China